Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

NCT04984941 | Completed

• 1 other identifier: 2012-047
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.

Conditions

Asthma; Allergic Rhinitis; Conjunctivitis; Atopic Dermatitis

Keywords

House dust mite; Der p 1; Der p 2; China

Outcome Measures

Primary Outcomes (7)

• Demographic Characteristics

  Describe the patient's basic information in detail, including age, gender, family history, etc

  1 year

• Der p 1 Serum IgE

  Prevalence of Der p 1 Serum IgE in HDM-Allergic Patients

  1 year

• Der p 2 Serum IgE

  Prevalence of Der p 2 Serum IgE in HDM-Allergic Patients

  1 year

• Dp, Der p 1 and Der p 2

  Relationship between Serum IgE Levels of Dp, Der p 1 and Der p 2

  1 year

• Factors associated with specific IgE against Der p 1

  Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 1

  1 year

• Factors associated with specific IgE against Der p 2

  Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 2

  1 year

• the Number of Affected Organs

  Association of Specific IgE Titers with the Number of Affected Organs

  1 year

Eligibility Criteria

• Age: 3 Years - 60 Years
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients were evaluated by a physician face-to-face, using a detailed questionnaire to establish the nature and severity of their clinical manifestations. The questionnaire also included demographic characteristics, a family history of allergic diseases and any other history of allergic disease.

You may qualify if:

• HDM-allergic patients reporting allergic rhinitis, conjunctivitis, asthma and/or atopic dermatitis and who had never undergone immunotherapy, were enrolled if they were sensitized to Dp as judged by ImmunoCAP ( ≥ 1 kU/l) and/or skin reaction index (SRI)by skin-prick test (SPT, a wheal diameter ≥ 0.5 mm).

You may not qualify if:

• Patients who refused to participate in the study.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

Second Affiliated Hospital，School of Medicine，Zhejiang University

Hangzhou, Zhejiang, China

Location

MeSH Terms

Conditions

Asthma; Rhinitis, Allergic; Conjunctivitis; Dermatitis, Atopic

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Rhinitis; Nose Diseases; Otorhinolaryngologic Diseases; Conjunctival Diseases; Eye Diseases; Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous

Study Officials

• Wang Huiying

  2nd affiliated Hospital,School of Medicine,Zhejiang University,China

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2021
• First Posted: August 2, 2021
• Study Start: March 1, 2013
• Primary Completion: March 1, 2014
• Study Completion: October 1, 2014
• Last Updated: August 2, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)