Peri-implantitis in HIV-positive Patients With Different Dental Prosthesis

NCT04983212 | Completed

• 1 other identifier: 10/INT/2020
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

Dental implants are widely used in human immunodeficiency virus (HIV)-positive patients, but the interaction between immune status and success of implant therapy, especially in such patients, is not clear. This study aimed to assess the prevalence of peri-implantitis in HIV-positive patients and to evaluate the presence of a possible correlation between the immunological profile and serological values of the same HIV-positive patients, of peri-implantitis, and of possible differences between all-on-4 and single crown/bridge prostheses in terms of peri-implant disease and the variables analyzed. This cross sectional study included 85 adult HIV-positive patients (394 implants) with at least one dental implant loaded for more than a year who were followed for at least one year. The patients were divided into patients with all-on-4 prosthesis and those with single crowns/bridges to assess the differences between the two types of prostheses in the inflammatory state, in the presence of mucositis and peri-implantitis, and in the variables analyzed. The following clinical parameters were assessed: full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing pocket depth (PPD) in six sites per implant and tooth (deepest value for each implant and tooth was registered), PI and BoP measured as presence/absence at six sites per implant and tooth, presence of suppuration, mobility (measured by manual palpation) and number of lost teeth.

Conditions

Peri-Implantitis

Keywords

peri-implantitis; HIV-positive; Mucositis

Outcome Measures

Primary Outcomes (1)

• prevalence of peri-implantitis

  peri-implantitis is characterized by inflammation of the peri-implant mucosa associated with a progressive loss of supporting bone

  01/01/2015 - 01/01/2020

Interventions

periodontal control OTHER

patient were called and visited in the dentistry department and gingival sulcus were gentle probed to assess gingiva and peri-implant tissues status

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with detected HIV infection and under retroviral therapy (HAART) that had positioned at least 1 dental implant with at least one year follow-up

You may qualify if:

• patients (\>18 years old) who had undergone prosthetic rehabilitation using one or more dental implants, with at least 1 year of follow-up after loading, and
• patients who had returned for a maintenance appointment at the Ville Turro Dental Clinic of Vita-Salute San Raffaele University in Milan
• patients under antiretroviral therapy (ART) at the same hospital.

You may not qualify if:

• Patients who discontinued antiretroviral therapy
• patients not undergoing therapy
• patients with uncontrolled systemic diseases (diabetes \[HbA1c\>7\])
• patients under treatment with any medications that may have an effect on bone turnover and mucosal healing (steroids, bisphosphonate therapy )
• Pregnancy or breastfeeding women
• patients who discontinued the oral maintenance (more than 1 appointment)

Sponsors & Collaborators

• Università Vita-Salute San Raffaele: lead

Study Sites (1)

Ville Turro, San Raffaele Hospital

Milan, 20128, Italy

Location

MeSH Terms

Conditions

Peri-Implantitis; HIV Seropositivity; Mucositis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Msc

Study Record Dates

• First Submitted: July 8, 2021
• First Posted: July 30, 2021
• Study Start: March 20, 2020
• Primary Completion: June 20, 2020
• Study Completion: July 20, 2020
• Last Updated: July 30, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)