NCT04979676

Brief Summary

Social anxiety often reaches its peak during adolescence and may hold a noteworthy impact both at the social and academic levels. Though some adolescents easily learn to adequately cope with it, others become overwhelmed by social fears and end up avoiding social events or facing them with intense suffering. Adolescents with social anxiety disorder (SAD) seldom seek professional help and often become adults with SAD, making it necessary to timely intervene during early stages of the disorder and determine what works better, why, and for whom when trying to change the course of social anxiety in adolescence. Cognitive therapy (CT) has been the treatment of choice for adult SAD, but research within adolescent samples is scarce. More recently, third-wave cognitive approaches, namely compassion-focused therapy (CFT) and acceptance and commitment therapy (ACT), have also proven effective in treating mental disorders, but their efficacy towards adolescents' SAD remains unclear. This research project intended to evaluate and compare the therapeutic efficacy of CT, CFT, and ACT as applied to adolescents with SAD, in comparison with waiting-listed, after intervention and over a 12-weeks and a 24-weeks follow-up, using a randomized parallel trial approach. This methodology will allow to test if intervened subjects diverge from the non-intervened SAD subjects, and if therapeutic change differs across intervention conditions. Therapeutic change process will be investigated, specifically if efficacy is mediated by change in the core constructs of each theoretical framework. Finally, moderators of change such the initial level of symptomology will be examined, as to determine which intervention works best for whom. The same procedures will be repeated for each intervention condition, namely recruitment, intervention, and assessment. This research will provide evidence on which form of therapy may be the optimal choice in to intervene in SAD in general, and when dealing with diverse specific vulnerabilities associated with social fears. It will also add to the field of empirically validated therapies, with a specific focus on adolescence. From a societal perspective, the project will assist in empowering schools to contribute to shape how their students act and develop into socially apt adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
92

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 15, 2019

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

July 15, 2021

Completed
13 days until next milestone

First Posted

Study publicly available on registry

July 28, 2021

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 27, 2023

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

May 17, 2024

Status Verified

May 1, 2024

Enrollment Period

4 years

First QC Date

July 15, 2021

Last Update Submit

May 16, 2024

Conditions

Keywords

Social Anxiety DisorderAdolescenceTherapeutic ChangeTherapeutic EfficacyTherapeutic Processes

Outcome Measures

Primary Outcomes (6)

  • Change in Social anxiety and Avoidance Scale for Adolescents - Anxiety scale

    Self-report instrument used to assess intensity of discomfort felt when: 1) Interacting in new social events, 2) Interacting with the opposite sex, 3) Interacting assertively, 4) Performing in formal social situations, 5) Performing in new social situations, and 6) Eating and drinking in public. Previous psychometric information indicates factorial validity for the six-factor measurement model via exploratory and confirmatory factor analyses, very good internal consistency values for all measures, convergent validity in relation to other measures of anxious and depressive symptoms, and measurement invariance across gender and age (Cunha et al., 2008; Vagos et al., 2013).

    Baseline, Week 10, Week 22, Week 34.

  • Change in Social anxiety and Avoidance Scale for Adolescents - Avoidance scale

    Self-report instrument used to assess frequency of avoidance of: 1) Interacting in new social events, 2) Interacting with the opposite sex, 3) Interacting assertively, 4) Performing in formal social situations, 5) Performing in new social situations, and 6) Eating and drinking in public. Previous psychometric information indicates factorial validity for the six-factor measurement model via exploratory and confirmatory factor analyses, very good internal consistency values for all measures, convergent validity in relation to other measures of anxious and depressive symptoms, and measurement invariance across gender and age (Cunha et al., 2008; Vagos et al., 2013).

    Baseline, Week 10, Week 22, Week 34.

  • Change in Sheehan disability scale

    Self-report instrument used to assess functional impairment caused by social anxiety symptomatology at three inter-related domains: school/ academic performance, social life, and family life. Has previously proved to be sensitive in discriminating the presence/ absence of psychopathology (Pinto-Gouveia et al., 2000).

    Baseline, Week 10, Week 22, Week 34.

  • Change in Clinical Global Impression Scale for Social Anxiety

    Clinician report of social anxiety symptoms. Has previously shown construct validity in relation to self-reported and clinician-administered measures of social anxiety, depression, impairment, and quality of life (Zaider et al., 2003). Includes measures of severity and change.

    Severity will be assessed at Baseline, Week 1, Week 2, Week 3, Week 4, Week 5, Week 6 Week 7, Week, 8, Week 9, Week 10, Week 34. Change will be assessed at Week 2, Week 3, Week 4, Week 5, Week 6 Week 7, Week, 8, Week 9, Week 10.

  • Social Anxiety Session Change Index

    Self-report instrument used to assess how participants in the experimental groups perceive to have changed since the beginning of treatment in level of anxiety in social/ performance events, in avoidance of those events, in concern about embarrassing or humiliating themselves, and in social anxiety related daily interference. Has previously shown adequate internal consistency, validity in relation to concurrent perceived change in fear of negative evaluation, validity in relation to social anxiety, and severity of symptoms and improvement as reported by the clinician (Hayes et al., 2008).

    Week 2, Week 3, Week 4, Week 5, Week 6 Week 7, Week, 8, Week 9, Week 10.

  • Change in diagnostic assignment

    Participants were/will be evaluated to verify the presence or absence of SAD at the 24-month follow-up/time 4 using the same semi-structured diagnostic interview used to assess initial inclusion/exclusion criteria.

    Baseline e week 34

Secondary Outcomes (8)

  • Change in Safety Behaviors in Social Situations Scale for Adolescents

    Baseline, Week 10, Week 22, Week 34.

  • Change in Social Thoughts and Beliefs Scale

    Baseline, Week 10, Week 22, Week 34.

  • Change in Self-focused Attention Scale

    Baseline, Week 10, Week 22, Week 34.

  • Change in Self-compassion Scale for Adolescents

    Baseline, Week 10, Week 22, Week 34.

  • Change in Other as Shamer Scale - Brief for Adolescents

    Baseline, Week 10, Week 22, Week 34.

  • +3 more secondary outcomes

Study Arms (4)

Cognitive Therapy

EXPERIMENTAL

Experimental group subjected to active individual psychotherapy based on developing skills relating to flexibility of attention, which in turn sustains adolescents adopting a more realistic perspective on social events and acting based on external (and not only internal) social information. Assessed weekly during the intervention period on symptom change. Also assessed at pre-intervention, post-intervention (i.e., 10 to 12 weeks later), 12-weeks follow, and 24-weeks follow-up.

Behavioral: Cognitive Therapy

Compassion-focused Therapy

EXPERIMENTAL

Experimental group subjected to active individual psychotherapy based on developing skills relating to flexibility of attention, which in turn sustains adolescents adopting a more realistic perspective on social events and acting based on external (and not only internal) social information. Assessed weekly during the intervention period on symptom change. Also assessed at pre-intervention, post-intervention (i.e., 10 to 12 weeks later), 12-weeks follow, and 24-weeks follow-up.

Behavioral: Compassion-focused Therapy

Acceptance and Commitment Therapy

EXPERIMENTAL

Experimental group subjected to active individual psychotherapy based on developing skills for acceptance, defusing, and focusing on the present moments, which in turn sustain acting in social events in line with ones valued actions instead of prioritizing the avoidance of negative internal experiences). Assessed weekly during the intervention period on symptom change. Also assessed at pre-intervention, post-intervention (i.e., 10 to 12 weeks later), 12-weeks follow, and 24-weeks follow-up.

Behavioral: Acceptance and Commitment Therapy

Waiting-list control

PLACEBO COMPARATOR

Group of participants with a main dignosis os social anxiety disorder not subjected to any psychological intervention within the current trial. Assessed at time 0, then at time 1 ten to twelve weeks after time 1, then again at time 3 twelve weeks later, and then again at time 4 another twelve weeks later (i.e., 24 weeks after time 1).

Behavioral: Cognitive TherapyBehavioral: Compassion-focused TherapyBehavioral: Acceptance and Commitment Therapy

Interventions

Experimental psychotherapy based on the cognitive model for social anxiety disorder, applied individually and remotely to participants fulfilling inclusion criteria.

Also known as: CT@TeenSAD
Cognitive TherapyWaiting-list control

Experimental psychotherapy based on the principles of the compassion-focused model, applied individually and remotely to participants fulfilling inclusion criteria.

Also known as: CFT@TeenSAD
Compassion-focused TherapyWaiting-list control

Experimental psychotherapy based on the principles of the acceptance and commitment model, applied individually and remotely to participants fulfilling inclusion criteria.

Also known as: ACT@TeenSAD
Acceptance and Commitment TherapyWaiting-list control

Eligibility Criteria

Age15 Years - 18 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Aged between 15 and 18 years old at screening phase;
  • Self-reported intensity of social anxiety higher than that reported by a normative comparable sample (Cunha et al., 2004);
  • Main diagnosis of Social Anxiety Disorder as evaluated via the Mini-Kid (Rijo et al., 2016).

You may not qualify if:

  • Psychotic symptoms or suicidal risk as assessed via the Mini-Kid (Rijo et al., 2016);
  • Being part of the special needs teaching system;
  • Currently receiving psychological intervention/counselling.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculdade de Psicologia e Ciências da Educação - Universidade de Coimbra

Coimbra, 3000-011, Portugal

Location

Related Publications (37)

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.

    BACKGROUND
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  • Boersma, K., Håkanson, A., Salomonsson, E., & Johansson, I. (2014). Compassion Focused Therapy to counteract shame, self-criticism and isolation. A replicated single case experimental study for individuals with social anxiety. Journal of Contemporary Psychotherapy, 45(2), 89-98. https://doi.org/10.1007/s10879-014-9286-8

    BACKGROUND
  • Carona, C., Rijo, D., Salvador, M.C., Castilho, P., & Gilbert, P. (2018). Compassion-focused therapy with children and adolescents. BJPsych Advances, 23(4), 240-252. https://doi.org/10.1192/apt.bp.115.015420

    BACKGROUND
  • Clark, D. M., & Wells, A. (1995). A cognitive model of social phobia. In G. Heimberg, M. R. M. R. Liebowitz, D. Hope, & F. Scheier (Eds.), Social phobia: Diagnosis, assessment, and treatment (pp. 69-93). New York: The Guilford Press.

    BACKGROUND
  • Creswell C, Leigh E, Larkin M, Stephens G, Violato M, Brooks E, Pearcey S, Taylor L, Stallard P, Waite P, Reynolds S, Taylor G, Warnock-Parkes E, Clark DM. Cognitive therapy compared with CBT for social anxiety disorder in adolescents: a feasibility study. Health Technol Assess. 2021 Mar;25(20):1-94. doi: 10.3310/hta25200.

    PMID: 33759742BACKGROUND
  • Cunha, M., Pinto-Gouveia, J.P., Alegre, S., & Salvador, M.C. (2004). Avaliação da ansiedade na adolescência: A versão portuguesa da SAS-A. Psychologica, 35, 249-263.

    BACKGROUND
  • Cunha, M., Pinto-Gouveia, J. P., & Salvador, M. C. (2008). Social fears in adolescence - The social anxiety and avoidance scale for adolescents. European Psychologist, 13(3), 197-213. https://doi.org/10.1027/1016-9040.13.3.1974

    BACKGROUND
  • Cunha, M. & Santos, A.M. (2011). Avaliação da inflexibilidade psicológica em adolescentes: Estudo das qualidades psicométricas da versão portuguesa do Avoidance and Fusion Questionnaire for Youth (AFQ-Y). Laboratório de Psicologia, 9, 133-146.

    BACKGROUND
  • Cunha, M., Xavier, A., & Vitória, I. (2013). Avaliação da auto-compaixão em adolescentes: Adaptação e qualidades psicométricas da Escala de Auto-Compaixão. Journal of Child and Adolescent Psychology, 4(2), 95-117.

    BACKGROUND
  • Dalrymple KL, Herbert JD. Acceptance and commitment therapy for generalized social anxiety disorder: a pilot study. Behav Modif. 2007 Sep;31(5):543-68. doi: 10.1177/0145445507302037.

    PMID: 17699117BACKGROUND
  • Essau CA, Lewinsohn PM, Olaya B, Seeley JR. Anxiety disorders in adolescents and psychosocial outcomes at age 30. J Affect Disord. 2014 Jul;163:125-32. doi: 10.1016/j.jad.2013.12.033. Epub 2014 Jan 2.

    PMID: 24456837BACKGROUND
  • Fontinho, A. & Salvador, M. C. (2012). O papel da atenção auto focada na fobia social na adolescência: validação da versão portuguesa da Escala de Atenção Auto Focada (SFA) e estudos preliminares [Unpublished master dissertation]. Faculty of Psychology and Educational Sciences of University of Coimbra.

    BACKGROUND
  • Gharraee, R., Rajrishi, K., Farani, A., Bolhari, J., & Farahani, H. (2018). A randomized controlled trial of compassion focused therapy for social anxiety disorder. Iranian Journal of Psychiatry and Behavioral Sciences, 12(4), e80945. https://doi.org/10.5812/ijpbs.80945

    BACKGROUND
  • Gill C, Watson L, Williams C, Chan SWY. Social anxiety and self-compassion in adolescents. J Adolesc. 2018 Dec;69:163-174. doi: 10.1016/j.adolescence.2018.10.004. Epub 2018 Oct 13.

    PMID: 30326397BACKGROUND
  • Halliburton, A. & Cooper, L. (2015). Applications and adaptations of Acceptance and Commitment Therapy (ACT) for adolescents. Journal of Contextual Behavioral Science, 1-11. https://doi.org/10.1016/j.jcbs.2015.01.002

    BACKGROUND
  • Hayes SA, Miller NA, Hope DA, Heimberg RG, Juster HR. Assessing Client Progress Session by Session in the Treatment of Social Anxiety Disorder: The Social Anxiety Session Change Index. Cogn Behav Pract. 2008 May 1;15(2):203-2011. doi: 10.1016/j.cbpra.2007.02.010.

    PMID: 25075171BACKGROUND
  • Khoramnia S, Bavafa A, Jaberghaderi N, Parvizifard A, Foroughi A, Ahmadi M, Amiri S. The effectiveness of acceptance and commitment therapy for social anxiety disorder: a randomized clinical trial. Trends Psychiatry Psychother. 2020 Jan-Mar;42(1):30-38. doi: 10.1590/2237-6089-2019-0003.

    PMID: 32321083BACKGROUND
  • Leigh E, Clark DM. Cognitive Therapy for Social Anxiety Disorder in Adolescents: A Development Case Series. Behav Cogn Psychother. 2016 Jan;44(1):1-17. doi: 10.1017/S1352465815000715. Epub 2015 Dec 7.

    PMID: 26640031BACKGROUND
  • Leigh E, Clark DM. Understanding Social Anxiety Disorder in Adolescents and Improving Treatment Outcomes: Applying the Cognitive Model of Clark and Wells (1995). Clin Child Fam Psychol Rev. 2018 Sep;21(3):388-414. doi: 10.1007/s10567-018-0258-5.

    PMID: 29654442BACKGROUND
  • Leigh E, Creswell C, Stallard P, Waite P, Violato M, Pearcey S, Brooks E, Taylor L, Warnock-Parkes E, Clark DM. Delivering cognitive therapy for adolescent social anxiety disorder in NHS CAMHS: a clinical and cost analysis. Behav Cogn Psychother. 2021 Mar 1:1-13. doi: 10.1017/S1352465821000035. Online ahead of print.

    PMID: 33645498BACKGROUND
  • Martins, M.J., Vieira, S., Salvador, M.C., Mackenzie, M.B., & Kocovski, M.L. (2015). Social anxiety - Acceptance and Action Questionnaire: Adaptation and validation in a Portuguese adolescent sample. Unpublished manuscript.

    BACKGROUND
  • Mavranezouli I, Mayo-Wilson E, Dias S, Kew K, Clark DM, Ades AE, Pilling S. The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. PLoS One. 2015 Oct 27;10(10):e0140704. doi: 10.1371/journal.pone.0140704. eCollection 2015.

    PMID: 26506554BACKGROUND
  • McNeil, D.W. (2010). In. Hofmann, G. & DiBartolo, P.M. (Eds), Social anxiety: Clinical, developmental and social perspectives (pp. 3-21). Oxford, UK: Elsevier.

    BACKGROUND
  • Ossman, W. A., Wilson, K. G., Storaasli, R. D., & McNeill, J. R. (2006). A preliminary investigation of the use of acceptance and commitment therapy in group treatment for social phobia. International Journal of Psychology and Psychological Therapy, 6(3), 397-416.

    BACKGROUND
  • Pinto-Gouveia, J., Cunham M. & Salvador, M. (2000). Um protocolo para a avaliação clínica da fobia social através de questionários de auto-resposta. In J. Pinto-Gouveia (Ed.), Ansiedade Social: Da timidez à fobia social (pp. 237-258). Coimbra: Quarteto Editora.

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    BACKGROUND
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    BACKGROUND
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    BACKGROUND
  • Vagos, P., & Pereira, A., & Cunha, M. (2013). Evaluating social fears in late adolescence: Study with a Portuguese Sample. European Journal of Developmental Psychology, 11(3), 373-385. https://doi.org/10.1080/17405629.2013.841093

    BACKGROUND
  • Vagos, P., Ribeiro da Silva, D., Brazão, N., Rijo, D. & Gilbert, P. (2016). Dimensionality and measurement invariance of the Other as Shamer Scale across diverse adolescent samples. Personality and Individual Differences, 98, 289-296. https://doi.org/10.10167j.psid.2010.04.046

    BACKGROUND
  • Werner KH, Jazaieri H, Goldin PR, Ziv M, Heimberg RG, Gross JJ. Self-compassion and social anxiety disorder. Anxiety Stress Coping. 2012;25(5):543-58. doi: 10.1080/10615806.2011.608842. Epub 2011 Sep 6.

    PMID: 21895450BACKGROUND
  • Zaider TI, Heimberg RG, Fresco DM, Schneier FR, Liebowitz MR. Evaluation of the clinical global impression scale among individuals with social anxiety disorder. Psychol Med. 2003 May;33(4):611-22. doi: 10.1017/s0033291703007414.

    PMID: 12785463BACKGROUND
  • Vagos, P., Figueiredo, D., Miguel, R., Ganho, A., Rijo, D., Lima, L., & Salvador, M.C. (2021). Ansiedade social na adolescência em contexto escolar: Uma experiência (não tão) normativa [Social anxiety in adolescence in schools: A (not so) normative experience]. Poster presented at the XVI Congresso Internacional Galego-Português de Psicopedagogia.

    BACKGROUND

MeSH Terms

Conditions

Phobia, Social

Interventions

Cognitive Behavioral TherapyAcceptance and Commitment Therapy

Condition Hierarchy (Ancestors)

Phobic DisordersAnxiety DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
The principal investigator is unaware of which participants are allocated to which condition; she is only aware of the inclusion criteria all participants must fulfill. The investigator and outcome assessor/data analyst are also unaware of treatment outcome and blind to the allocation condition.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: This work uses a randomized and parallel clinical trial methodology (although the different parallel conditions are collected sequentially over the duration of the trial) to assess the effectiveness of three therapeutic approaches (i.e., CT, CFT and ACT) with adolescents with SAD, compared to a waiting-list control group. Originally, participants were to be sequentially and over time recruited and allocated to the different parallel conditions (i.e., assignment to CT or to a wait-list control condition in the first year; assignment to CFT or to a wait-list control condition in the second year, and assignment to ACT in the third year). However, the Covid-19 pandemic forced us to adapt the interventions to an online individual format thus delaying the assignment to the experimental conditions. So, all participants recruited in the first year were assigned to the wait-list control group and later randomly allocated to an experimental condition by the responsible investigator.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

July 15, 2021

First Posted

July 28, 2021

Study Start

March 15, 2019

Primary Completion

February 27, 2023

Study Completion

December 31, 2023

Last Updated

May 17, 2024

Record last verified: 2024-05

Data Sharing

IPD Sharing
Will not share

IPD will not be shared as participants were guaranteed anonymity and confidentiality of their individual data. Datasets with alphanumerical identities given to each participant may be made available, either by publishing data or upon reasonable request directed at with the principal investigator.

Locations