NCT04974242

Brief Summary

POWER is a pragmatic multi-centre, external pilot randomised controlled trial with feasibility objectives using a parallel group design with 1:1 allocation ratio and integrated qualitative study. The study aims to answer the question: In adult patients diagnosed with tears of the rotator cuff and awaiting elective surgical repair, is it feasible to conduct a future, fully powered, multi-site RCT to test the hypothesis that physiotherapist-led exercise is superior to waiting-list control in terms of clinical and cost-effectiveness?

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
76

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2021

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 9, 2021

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 23, 2021

Completed
2 months until next milestone

Study Start

First participant enrolled

September 29, 2021

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2022

Completed
Last Updated

October 11, 2021

Status Verified

October 1, 2021

Enrollment Period

10 months

First QC Date

June 9, 2021

Last Update Submit

October 7, 2021

Conditions

Outcome Measures

Primary Outcomes (11)

  • Numbers of eligible patients.

    Numbers of patients screened and then deemed eligible will be reported descriptively.

    6 months

  • Rate of recruitment.

    Numbers of patients approached and then randomised as a proportion of the number of eligible patients will be reported descriptively.

    6 months

  • Reasons for patients not wanting to participate.

    Reasons for patients not wanting to participate will be reported descriptively.

    6 months

  • Treatment fidelity (numbers of participants who receive physiotherapy) relating to the programme of physiotherapist-led exercise.

    Numbers of participants who receive physiotherapy will be reported descriptively.

    6 months

  • Treatment fidelity (number of appointments attended) relating to the programme of physiotherapist-led exercise.

    The number of appointments attended will be reported descriptively.

    6 months

  • Treatment fidelity (self-report exercise adherence) relating to the programme of physiotherapist-led exercise.

    Self-report exercise adherence (intervention group only) will be reported descriptively.

    6 months

  • Completion rate of clinical outcome measures.

    The proportion of clinical outcome questionnaires completed at 6-weeks post-randomisation, including via minimal data collection, will be reported descriptively.

    6 weeks

  • Completion rate of clinical outcome measures.

    The proportion of clinical outcome questionnaires completed at three months post-randomisation, including via minimal data collection, will be reported descriptively.

    3 months

  • Completion rate of clinical outcome measures.

    The proportion of clinical outcome questionnaires completed at six months post-randomisation, including via minimal data collection, will be reported descriptively.

    6 months

  • Number and nature of adverse events.

    The number and nature of adverse events which occur will be reported descriptively overall and by study arm.

    6 months

  • Proportion of participants who report an intention to proceed to surgery or who have received surgery.

    The proportion of participants who report an intention to proceed to surgery or who have received surgery within six-months post randomisation will be reported descriptively.

    6 months

Secondary Outcomes (4)

  • Pain and disability assessed using the Shoulder Pain & Disability Index (SPADI)

    6 weeks, 3 and 6 months post-randomisation

  • Health related quality of life assessed using the EQ-5D-5L

    6 weeks, 3 and 6 months post-randomisation

  • Days lost from work due to the shoulder problem

    6 weeks, 3 and 6 months post-randomisation

  • Days lost from driving

    6 weeks, 3 and 6 months post-randomisation

Study Arms (2)

Physiotherapist-led exercise

EXPERIMENTAL

Structured and progressive physiotherapist-led exercise programme. Reflective of current guidance for exercise programmes for people with rotator cuff disorders, an individualised programme developed in relation to the participant's specific goals will be prescribed by the physiotherapist and supported over approximately six contact sessions across a 12-week period.

Other: Physiotherapist-led exercise

Waiting-list control

NO INTERVENTION

Continue on the waiting list for rotator cuff repair surgery, as per usual care.

Interventions

A programme of physiotherapist-led exercise over approximately 12 weeks.

Physiotherapist-led exercise

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patients on the elective orthopaedic waiting list for surgical repair of the rotator cuff.

You may not qualify if:

  • Unable to provide informed consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospitals Derby and Burton NHS Foundation Trust

Derby, Derbyshire, DE22 3DT, United Kingdom

RECRUITING

MeSH Terms

Conditions

Rotator Cuff Injuries

Condition Hierarchy (Ancestors)

RuptureWounds and InjuriesShoulder InjuriesTendon Injuries

Study Officials

  • Chris Littlewood

    Manchester Met University

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 9, 2021

First Posted

July 23, 2021

Study Start

September 29, 2021

Primary Completion

August 1, 2022

Study Completion

October 1, 2022

Last Updated

October 11, 2021

Record last verified: 2021-10

Data Sharing

IPD Sharing
Will share

The anonymised datasets generated during and/or analysed during the current study are/will be available upon request from the chief investigator. Only de-identified data will be available for request in aggregated format or at the level of the individual participant.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Following publication of the study results and for up to 10 years thereafter.
Access Criteria
An email request should be sent to the chief investigator outlining the type of data to be obtained, the reason for obtaining this data (research question / objective), and the timing for when the data is required to be available (start date/end date). The chief investigator will check that the data set requested is appropriately suited to answer the research question/objective and that the request fits with the original ethical approval and participant consent and adheres to funder and legal restrictions.

Locations