Movement Disorders Analysis Using a Deep Learning Approach

NCT04974034 | Completed

• 1 other identifier: CLEA-2019-83
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Bradykinesia is a key parkinsonian feature yet subjectively assessed by the MDS-UPDRS score, making reproducible measurements and follow-up challenging. In a Movement Disorder Unit, the investigators acquired a large database of videos showing parkinsonian patients performing Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III protocols. Using a Deep Learning approach on these videos, the investigators aimed to develop a tool to compute an objective score of bradykinesia from the three upper limb tests described in the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III.

Conditions

Bradykinesia; Parkinson Disease; Hypokinesia; Akinesia; Parkinsonian Syndrome; Parkinsonian Disorders

Keywords

Deep Learning; Bradykinesia; Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III score

  Automatic Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III for hand bradykinesia including the three following specific tasks (finger tapping, hand movements and pronation-supination movements of hand). The minimum score is 0. The maximum score is 12 Higher scores mean wors outcome

  1 day

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients seen by a neurologist in the department of Neurology at Avicenne Hospital (Bobigny, France) between June 2019 and December 2020 were recorded during MDS-UPDRS examination. The investigators also included healthy volunteers on a voluntary basis.

You may qualify if:

• Age \> 18 years

You may not qualify if:

• Refusal of participation

Sponsors & Collaborators

• Hospital Avicenne: lead

Study Sites (1)

Hospital Avicenne

Bobigny, Seine Saint Denis, 93000, France

Location

MeSH Terms

Conditions

Hypokinesia; Parkinson Disease; Parkinsonian Disorders

Condition Hierarchy (Ancestors)

Dyskinesias; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Clément Desjardins, MD

  Hospital Avicenne

  PRINCIPAL INVESTIGATOR

• Bertrand Degos, MD,PhD

  Hospital Avicenne

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Neurology Resident

Study Record Dates

• First Submitted: July 3, 2021
• First Posted: July 23, 2021
• Study Start: June 1, 2019
• Primary Completion: November 18, 2020
• Study Completion: December 31, 2020
• Last Updated: July 23, 2021

Record last verified: 2021-07

Locations

FR (1)