Movement Error-processes and Sensorimotor Adaptation in Parkinsonian Patient

NCT03371407 | Recruiting

• 2 other identifiers: 2016-362016-A01196-45
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present project is to document the relationship between the behavioral deficits and the electrophysiological anomalies observed in PD patients in tasks involving motor adaptation to visual or mechanical perturbations.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• The electrophysiological (EEG) activity by the BioSemi 64 electrodes system

  Hertz identification of electrodes where signal fluctuations are the most important.

  6 months

Study Arms (3)

Parkinsonian patient under dopaminergic medication

Other: Assessment of behavioral performance and the electrophysiological (EEG) activity in PD patients during the early and more advanced stages of the pathology

Parkinsonian patient without dopaminergic medication

Other: Assessment of behavioral performance and the electrophysiological (EEG) activity in PD patients during the early and more advanced stages of the pathology

Control participants

Other: Assessment of behavioral performance and the electrophysiological (EEG) activity in PD patients during the early and more advanced stages of the pathology

Interventions

Assessment of behavioral performance and the electrophysiological (EEG) activity in PD patients during the early and more advanced stages of the pathology OTHER

Assessment of behavioral performance and the electrophysiological (EEG) activity in PD patients during the early and more advanced stages of the pathology, using an instrumentation, called the Kinarm, which assess objectively sensory, motor and cognitive functions

Control participants; Parkinsonian patient under dopaminergic medication; Parkinsonian patient without dopaminergic medication

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients suffering from Parkinson disease

You may qualify if:

• Patient aged over 18 years
• Right-handed patients , following the Modified Edinburgh Handedness Inventory
• Patient with Parkinson's disease according to Gibb criteria
• Idiopathic Parkinson's Disease with a history of more than 5 years
• Stimulation electrodes implanted in the 2 subthalamic nuclei in the Functional and Stereotactic Neurosurgery Department of La Timone Hospital (Pr REGIS).
• Dopa-sensitivity greater than 50%
• Absence of signs of cognitive impairment
• Patient who agreed to participate in the study and signed informed consent
• Patient affiliated with a health insurance

You may not qualify if:

• Person not likely to participate in the entire study
• Pregnant or likely to be pregnant during the year
• Patients unable to give their informed consent (detainees, adults under guardianship)
• Person unable to understand the nature and purpose of the study, or presneting with understanding difficulties which could compromise the proper conduct of the study
• Person refusing to sign the Informed Consent Form
• A person who is able to give his or her consent but unable to read / write French language
• patient who can not participate in an MRI study according to the criteria listed in the attached form.

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Service de Neurologie, Hôpital de la Timone, Assistance Publique Hôpitaux de Marseille

Marseille, 13005, France

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Urielle DESALBRES

  Assistance Publique Hôpitaux de Marseille

  STUDY DIRECTOR

Central Study Contacts

Alexandre EUSEBIO, MD, PHD

CONTACT

+33491384333; alexandre.eusebio@ap-hm.fr

Camille DELANNOY

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2017
• First Posted: December 13, 2017
• Study Start: July 4, 2019
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: January 5, 2024

Record last verified: 2024-01

Locations

FR (1)