NCT04960111

Brief Summary

The innovative aspect of this research is the possibility of combining the data collected with radiostereometric model based Radiostereometry with the data collected through the Galeazzi Institute Registry.This opens the prospect of an earlier identification of patients undergoing prosthetic knee replacement with initial aseptic loosening.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for not_applicable knee-osteoarthritis

Timeline
Completed

Started Dec 2019

Longer than P75 for not_applicable knee-osteoarthritis

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 10, 2019

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

July 2, 2021

Completed
11 days until next milestone

First Posted

Study publicly available on registry

July 13, 2021

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 10, 2022

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 10, 2023

Completed
Last Updated

July 19, 2021

Status Verified

July 1, 2021

Enrollment Period

3 years

First QC Date

July 2, 2021

Last Update Submit

July 13, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • micro-movement detection with radiostereometry and the patient's perception, measured with Short Form health survey12 at 12 month after surgery.

    evaluate correlation between levels of micro-movement of the prosthetic components using radiostereometry model based RSA and the patient's perception, measured with Short Form health survey12 at 12 month after surgery.

    12 months

Secondary Outcomes (1)

  • correlation of micromovements and Patient reported outcomes at follow up

    baseline to 24 months

Study Arms (1)

knee arthroplasty with radiostereometry tecnique

EXPERIMENTAL

patient underwent total knee arthroplasty with insertion of microsphere in tantallium for radiostereometry tecnique.

Device: RSA

Interventions

RSADEVICE

application of tantalium microsphere around knee prosthesis and RSA X-ray post operative to detect early mobilization in follow up.

knee arthroplasty with radiostereometry tecnique

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age more than 18
  • patients underwent total knee arthroplasty without controindications for this procedure
  • patients enrolled in PatientsReportedOutcomesMeasureS (PROMS) study

You may not qualify if:

  • age less than 18
  • comorbility that make difficult come back for follow-up
  • patients with allergy at materials used in Radiostereometry tecnique
  • infection
  • anemia, obesity, osteoporosis
  • pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Istituto Ortopedico Galeazzi

Milan, 20161, Italy

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 2, 2021

First Posted

July 13, 2021

Study Start

December 10, 2019

Primary Completion

December 10, 2022

Study Completion

July 10, 2023

Last Updated

July 19, 2021

Record last verified: 2021-07

Locations