Evaluating Fracture Risk Assessment Tools (FRAX) From Different Regions in Central South Chinese Postmenopausal Women

NCT04960033 | Completed DMC

• 1 other identifier: Sheng zhifeng
• Study Type: observational
• Target: 264
• Locations: 1 country
• Sites: 1

Brief Summary

We evaluated fracture risk assessment tools (FRAXs) from different regions in Chinese postmenopausal women.

Conditions

Osteoporosis Fracture

Keywords

FRAX; osteoporosis; Chinese population

Outcome Measures

Primary Outcomes (1)

• Osteoporosis fracture

  The 10-year MOF probability and the 10-year HF probability were calculated using the FRAXs of different regions (mainland China, Hong Kong, Taiwan, and Asia-America). Subjects were deemed as high-risk for osteoporotic fracture if the 10-year probability of MOF was ≥20% or the 10-year probability of HF was ≥3%.

  2017years

Study Arms (2)

Osteoporosis fracture

The 10-year MOF probability and the 10-year HF probability were calculated using the FRAXs of different regions (mainland China, Hong Kong, Taiwan, and Asia-America). Subjects were deemed as high-risk for osteoporotic fracture if the 10-year probability of MOF was ≥20% or the 10-year probability of HF was ≥3%.

Behavioral: FRAX

women without osteoporosis fracture

The 10-year MOF probability and the 10-year HF probability were calculated using the FRAXs of different regions (mainland China, Hong Kong, Taiwan, and Asia-America). Subjects were deemed as high-risk for osteoporotic fracture if the 10-year probability of MOF was \<20% or the 10-year probability of HF was \<3%.

Behavioral: FRAX

Interventions

FRAX BEHAVIORAL

The 10-year MOF probability and the 10-year HF probability were calculated using the FRAXs of different regions (mainland China, Hong Kong, Taiwan, and Asia-America). Subjects were deemed as high-risk for osteoporotic fracture if the 10-year probability of MOF was ≥20% or the 10-year probability of HF was ≥3%.

Osteoporosis fracture; women without osteoporosis fracture

Eligibility Criteria

• Age: 50 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Postmenopausal women aged ≥50 years were randomly selected from community centers in Changsha City, Hunan Province, China in September 2017.

You may qualify if:

• Postmenopausal women aged ≥50 years were randomly selected from community centers in Changsha City, Hunan Province, China in September 2017. Menopause was defined as the absence of menstrual cycles for at least one year. All subjects were noninstitutionalized and in good health.

Sponsors & Collaborators

• Central South University: lead

Study Sites (1)

The 2nd Xiangya Hospital, Central South University

Changsha, Hunan, 410011, China

Location

Related Publications (1)

• Zhang Z, Ou Y, Sheng Z, Liao E. How to decide intervention thresholds based on FRAX in central south Chinese postmenopausal women. Endocrine. 2014 Mar;45(2):195-7. doi: 10.1007/s12020-013-0076-y. Epub 2013 Oct 22.

  PMID: 24146412 BACKGROUND

MeSH Terms

Conditions

Osteoporotic Fractures; Osteoporosis

Condition Hierarchy (Ancestors)

Fractures, Bone; Wounds and Injuries; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Central South University

Study Record Dates

• First Submitted: July 2, 2021
• First Posted: July 13, 2021
• Study Start: September 1, 2017
• Primary Completion: September 30, 2017
• Study Completion: September 30, 2017
• Last Updated: July 13, 2021

Record last verified: 2021-07

Locations

CN (1)