NCT04954274|Active Not RecruitingPhase 3DMC
Improvement of Live Babies Rates After ICSI, Using cpFT
FERTICSI
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Sponsor study identifier
interventional
366
1 country
1
Study Start
July 29, 2021
Actual (reported)Primary Completion
July 29, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 29, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Demonstrate the improvement of the live births rate after ICSI by supplementing the pre-ICSI incubation medium of oocytes and that of preimplantation embryos with cpFT at the 1st embryo transfer for women under 37 years old.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 29, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 29, 2021
Actual (reported)July 8, 2021
Actual (reported)July 29, 2021
Actual (reported)July 29, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 29, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Live birth rate after the first embryo transfer
Demonstration of the improvement in the rate of live births after ICSI by supplementing the pre-ICSI incubation medium of oocytes and that of preimplantation embryos with cpFT (1µM) during the 1st embryo transfer in women under 37 years of age.
54 months after the first randomization
Level of Metaphase II oocytes
During the randomization period, which is 42 months.
Quality of the embryonic culture
42 months after the first randomization
Evaluation of the kinetics of embryonic development when possible.
42 months after the first randomization
Embryonic quality at the blastocyst stage
Day 5-6 after ICSI
Quality of the embryos after vitrification
Day 5-6 after ICSI
Treated by supplementation of the culture medium with the molecule.
No supplementation
Upon retrieval, the oocyte will be decoronized and incubated prior to ICSI procedure into CSCC-M medium supplemented with the molecule. After ICSI, the zygote will be incubated in CSCM-C medium supplemented with the peptide.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Department Biology of Reproduction, Hospital Cochin AP-HP
Paris, 75014, France
Barraud-Lange V, Naud-Barriant N, Ducot B, Chambris S, Bomsel M, Wolf JP, Ziyyat A. Cyclic QDE peptide increases fertilization rates and provides healthy pups in mouse. Fertil Steril. 2009 May;91(5 Suppl):2110-5. doi: 10.1016/j.fertnstert.2008.05.088. Epub 2008 Aug 9.
Ziyyat A, Naud-Barriant N, Barraud-Lange V, Chevalier F, Kulski O, Lemkecher T, Bomsel M, Wolf JP. Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition. Hum Reprod. 2005 Dec;20(12):3452-8. doi: 10.1093/humrep/dei241. Epub 2005 Aug 11.
Jean Philippe Mr WOLF, MD-PhD
AP-HP, Hospital Cochin
First Submitted
April 29, 2021
First Posted
July 8, 2021
Study Start
July 29, 2021
Actual (reported)Primary Completion
COMPARING TWO PROTOCOLS FOR FINAL OOCYTE MATURATION IN POOR RESPONDERS UNDERGOING GnRH-ANTAGONIST ICSI CYCLES
Contact the study team to confirm eligibility.
July 29, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 29, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
November 28, 2025
Record last verified: 2025-11
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Source: ClinicalTrials.gov.
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