Candidate Gene Association Study With Injury in Elite Male Youth Football Players
1 other identifier
observational
123
1 country
2
Brief Summary
Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2019
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2019
CompletedFirst Submitted
Initial submission to the registry
May 31, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 31, 2021
CompletedFirst Posted
Study publicly available on registry
July 7, 2021
CompletedJuly 7, 2021
July 1, 2021
1.5 years
May 31, 2021
July 6, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of non-injured and injured participants with injury risk alleles
Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury
8 Years
Interventions
COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722, ACTN3 rs1815739, ACE rs1799752, ESR1 rs2234693, MMP3 rs679620, VDR rs2228570 and GDF5 rs143383
Eligibility Criteria
Elite male youth football players
You may qualify if:
- Elite Male Footballer Player Registered at Fulham Football Club
You may not qualify if:
- Female no longer registered at Fulham Football Club
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- St Mary's University Collegelead
- Fulham Football Clubcollaborator
Study Sites (2)
Fulham Football Club
London, New Malden, KT3 6PT, United Kingdom
St Mary's University, Twickenham
London, Twickenham, TW1 4SX, United Kingdom
Biospecimen
DNA
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 31, 2021
First Posted
July 7, 2021
Study Start
December 1, 2019
Primary Completion
May 31, 2021
Study Completion
May 31, 2021
Last Updated
July 7, 2021
Record last verified: 2021-07
Data Sharing
- IPD Sharing
- Will not share