Multicomponent Exercise in People With Dementia
Effect of Multicomponent Exercise on Cognitive Function and Activities of Daily Living in People With Dementia
1 other identifier
interventional
52
0 countries
N/A
Brief Summary
People with dementia shows a decline in cognition, such as memory, executive function (EF), language, attention, and spatial orientation that is significant enough to interfere with the independence and daily functioning. Previous studies reported that multicomponent exercise improved EF in people with mild cognitive impairment and independence of ADL in those with Alzheimer's disease. However, few studies investigated whether multicomponent exercise improved EF, memory, and ADL in people with dementia. Therefore, the purposes of this study are to examine 1) the effect of multicomponent exercise on EF, memory, and ADL in people with mild to moderate dementia; 2) the correlation between change in EF and ADL; 3) the correlation between change in memory and ADL.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2021
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 18, 2021
CompletedFirst Posted
Study publicly available on registry
July 6, 2021
CompletedStudy Start
First participant enrolled
September 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedAugust 24, 2021
August 1, 2021
1.3 years
June 18, 2021
August 21, 2021
Conditions
Outcome Measures
Primary Outcomes (5)
Mini-Mental State Examination
It is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Higher scores mean a better outcome.
Change from baseline at 9 week
Chinese version of Verbal learning test
It is a 9-point measurement to evaluate memory. Higher scores mean a better outcome.
Change from baseline at 9 week
Chinese version of Stroop color and word test
It is a measurement to evaluate inhibition control.
Change from baseline at 9 week
Digit span test
It is a measurement to evaluate working memory.
Change from baseline at 9 week
Trail making test - Chinese version
It is a measurement to evaluate cognitive flexibility.
Change from baseline at 9 week
Secondary Outcomes (7)
Barthel index
Change from baseline at 9 week
Instrumental activities of daily living (IADL) scale
Change from baseline at 9 week
Chinese version of Quality of Life in Alzheimer Disease Scale
Change from baseline at 9 week
Time up and go test
Change from baseline at 9 week
30-second chair stand test
Change from baseline at 9 week
- +2 more secondary outcomes
Study Arms (2)
Multicomponent exercise group
EXPERIMENTALVideo home exercise group
ACTIVE COMPARATORInterventions
The intervention is a 60-minute session, 3 times/week, totaling 9 weeks. Multicomponent exercise included strengthening, balance training, aerobic dance, and stretching
The intervention is a 60-minute session, 3 times/week, totaling 9 weeks. Video home exercise included four limbs mobility exercise, stretching, strengthening, and aerobic exercise
Eligibility Criteria
You may qualify if:
- Age: 60-80 y/o
- Mini-Mental State Examination: 10-26
- Clinical Dementia Rating: 1-2
- Walk at least 6 meters independently (with or without walking aids)
You may not qualify if:
- Any other diagnosis of neurological diseases or musculoskeletal problems (Except dementia)
- Physical or psychological comorbidities that affect performance during assessment or intervention
- Already participating in other physical training in the last 1 month
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 18, 2021
First Posted
July 6, 2021
Study Start
September 1, 2021
Primary Completion
December 31, 2022
Study Completion
December 31, 2022
Last Updated
August 24, 2021
Record last verified: 2021-08