NCT04947488

Brief Summary

Long Covid could be much more frequent than it is thought to be. Few dwell on the great problem represented by the post covid syndrome. The virus often leaves important marks on our body, and those who recover face problems of various kinds: chronic fatigue, shortness of breath, dry cough, headache, cognitive difficulties. On the duration and resolution of this syndrome, now recognized as a highly debilitating condition, there are still no great answers: for this reason it is always important to emphasize that contracting Covid, even in a not serious form, still means exposing oneself to long-term risks that are still not well codified by the scientific community. Guidelines and more tools are expected to best assist these patients.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2021

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 18, 2021

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

June 30, 2021

Completed
1 day until next milestone

First Posted

Study publicly available on registry

July 1, 2021

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 18, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 18, 2022

Completed
Last Updated

May 17, 2022

Status Verified

May 1, 2022

Enrollment Period

1.3 years

First QC Date

June 30, 2021

Last Update Submit

May 16, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • 6 minute walking test to evaluate Fatigue

    Effect of Bioarginina C on the prolonged fatigue

    30 days

Study Arms (2)

Bioarginina C

ACTIVE COMPARATOR

vials based on L-arginine and liposomal vitamin C

Dietary Supplement: Bioarginina C

Placebo

PLACEBO COMPARATOR

vials without L-arginine and liposomal vitamin C

Dietary Supplement: Bioarginina C

Interventions

Bioarginina CDIETARY_SUPPLEMENT

Dietary supplement vials

Bioarginina CPlacebo

Eligibility Criteria

Age20 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • subjects with proven positivity to the molecular test for Sars-cov2 with demonstration of microbiological healing patients discharged from FPG or other hospital structures; or only contact in PS; or home management age: range 20-60 years Fatigue operationalized as an affirmative answer to item "7" (CES-D)

You may not qualify if:

  • Pharmacological therapies with possible interactions with the mechanisms / processes under study (e.g. antihypertensive drugs, cortisone drugs, NSAIDs, immunosuppressants, nitrates)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Barbara Maglione

Napoli, Italy

RECRUITING

MeSH Terms

Conditions

Fatigue Syndrome, ChronicInflammation

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal DiseasesEncephalomyelitisNeuroinflammatory DiseasesNervous System DiseasesNeuromuscular DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor

Study Record Dates

First Submitted

June 30, 2021

First Posted

July 1, 2021

Study Start

June 18, 2021

Primary Completion

September 18, 2022

Study Completion

November 18, 2022

Last Updated

May 17, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will not share

Locations