Ground Beef and Cardiovascular Disease

NCT04945980 | Completed

• 1 other identifier: IRB2005-0435
• Study Type: interventional
• Target: 27
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study tested the hypothesis that ground beef high in monounsaturated fat (MUFA) and low in saturated fat (SFA) would increase the high-density lipoprotein-cholesterol concentration and low-density lipoprotein particle diameter. In a crossover dietary intervention, 27 free-living normocholesterolemic men completed treatments in which five 114-g ground beef patties/week were consumed for 5 weeks with an intervening 4-week washout period. Patties contained 24% total fat with a MUFA:SFA ratio of either 0.71 (low MUFA, from pasture-fed cattle) or 1.10 (high MUFA, from grain-fed cattle).

Conditions

Lipoprotein Metabolism Disorder

Keywords

ground beef; lipoprotein cholesterol; cardiovascular disease

Outcome Measures

Primary Outcomes (2)

• Lipoprotein cholesterol

  Plasma very low-density, low-density, and high-density cholesterol concentrations

  5 weeks

• Low-density lipoprotein particle size

  Plasma low-density lipoprotein particle size

  5 weeks

Secondary Outcomes (1)

• C-reactive protein

  5 weeks

Study Arms (2)

Low-MUFA ground beef

EXPERIMENTAL

Participants consumed ground beef low in monounsaturated fatty acids.

Dietary Supplement: Ground beef

High-MUFA ground beef

EXPERIMENTAL

Participants consumed ground beef high in monounsaturated fatty acids.

Dietary Supplement: Ground beef

Interventions

Ground beef DIETARY_SUPPLEMENT

Ground beef naturally low in monounsaturated fatty acids or naturally high in monounsaturated fatty acids

High-MUFA ground beef; Low-MUFA ground beef

Eligibility Criteria

• Age: 23 Years - 60 Years
• Gender Eligibility Details: Males
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Non-smoking

You may not qualify if:

• Consuming restrictive diets, cholesterol-lowering medications

Sponsors & Collaborators

• Texas A&M University: lead

Related Publications (1)

• Gilmore LA, Walzem RL, Crouse SF, Smith DR, Adams TH, Vaidyanathan V, Cao X, Smith SB. Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men. J Nutr. 2011 Jun;141(6):1188-94. doi: 10.3945/jn.110.136085. Epub 2011 Apr 27.

  PMID: 21525253 RESULT

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Stephen Smith, Ph.D.

  Texas A&M University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants were blinded to treatments.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A 2-period, randomized cross-over design was used. Each participant completed two 5-wk diet interventions in a randomly assigned order with a 4-wk washout period between the test diet interventions.

Study Record Dates

• First Submitted: June 25, 2021
• First Posted: June 30, 2021
• Study Start: March 27, 2006
• Primary Completion: May 31, 2006
• Study Completion: May 31, 2006
• Last Updated: June 30, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share