Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability

NCT04945278 | Recruiting

• 1 other identifier: 29BRC20.0283
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to establish whether there are differences in self-recognition and self/other distinction in subjects with psychological vulnerability compared to healthy volunteer controls.

Conditions

Psychosis of Childhood Borderline; Psychotic Disorder

Keywords

Mental Vulnerability; Self-recognition; Psychosis High-Risk State; Self-other Distinction; Double Mirror Paradigm; Schizophrenia

Outcome Measures

Primary Outcomes (1)

• Average of the three M1

  Average of the three M1 thresholds obtained from the "round trip" manipulation repeated three times, the M1 threshold corresponding to the level of luminosity from which a subject begins to recognize himself when his own image gradually appears (during the passage of the condition glass in mirror condition).

  Inclusion

Secondary Outcomes (7)

• The average of the three M2

  Inclusion

• Results to tests for early prodromal symptoms assessed by SPI-A (Schizophrenia Prediction Instrument for Adults)

  Inclusion

• Results to tests for early prodromal symptoms assessed by PQ16 (Prodromal Questionnaire - 16)

  Inclusion

• Results to tests for early prodromal symptoms assessed by EASE(xamination of Anomalous Self-Experience)

  Inclusion

• Results to tests for later prodromal symptoms

  Inclusion

Study Arms (2)

Patients

OTHER

Both patients and healthy volunteers arms will undergo the double mirror test within a day. But the patients arm will additionally respond to the EASE test.

Other: Double mirror device ALTER-EGO; Other: EASE test

Healthy volunteers

OTHER

Both patients and healthy volunteers arms will undergo the double mirror test within a day.

Other: Double mirror device ALTER-EGO

Interventions

EASE test OTHER

The patient will have to answer the EASE test which is a specific test to detect patient with high risk of psychosis or schizophrenia

Patients

Double mirror device ALTER-EGO OTHER

The patient and his matched healthy volunteer will be placed on each side of the double mirror device ALTER-EGO. Both sides will be lightened alternatively or at the same time by lights, so according to the light intensity, the subject will see himself in a mirror or the other person throw a classic window. The light intensity will vary from 0 to 100% and to 100% to 0% alternatively from each side of the mirror. At each 10% variation of one side, both patient and volunteer will have to answer that question : "who do you see more : him/her or yourself ?"

Healthy volunteers; Patients

Eligibility Criteria

• Age: 15 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Aged from 15 to 25 years
• Subject meeting the Ultra High Risk criteria at CAARMS and / or SPI-A
• Signature of the consent (participants and parents for minors)
• Subject affiliated to the social security scheme or benefiting from such a scheme
• Aged from 15 to 25 years
• Subject not familiar to the patient to whom it is matched
• Signature of the consent (participants and parents for minors)
• Subject affiliated to the social security scheme or benefiting from such a scheme

You may not qualify if:

• History of epilepsy and / or migraine (due to the epileptogenic potential of light stimuli)
• Refusal of participation of the minor even if the legal representatives want the subject to participate in the study
• Claustrophobia
• Wearing glasses
• Abnormal right and left visual acuity without contact lenses
• Distinctive signs on the face which cannot be temporarily removed
• Subject under legal protection (curators / guardianship) or deprived of liberty

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

CHRU BREST Hôpital de Bohars

Bohars, 29280, France

RECRUITING

Related Publications (8)

• Frith CD, Corcoran R. Exploring 'theory of mind' in people with schizophrenia. Psychol Med. 1996 May;26(3):521-30. doi: 10.1017/s0033291700035601.

  PMID: 8733211 BACKGROUND

• Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rossler A, Schultze-Lutter F, Keshavan M, Wood S, Ruhrmann S, Seidman LJ, Valmaggia L, Cannon T, Velthorst E, De Haan L, Cornblatt B, Bonoldi I, Birchwood M, McGlashan T, Carpenter W, McGorry P, Klosterkotter J, McGuire P, Yung A. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry. 2013 Jan;70(1):107-20. doi: 10.1001/jamapsychiatry.2013.269.

  PMID: 23165428 BACKGROUND

• Thirioux B, Wehrmann M, Langbour N, Jaafari N, Berthoz A. Identifying Oneself with the Face of Someone Else Impairs the Egocentered Visuo-spatial Mechanisms: A New Double Mirror Paradigm to Study Self-other Distinction and Interaction. Front Psychol. 2016 Aug 25;7:1283. doi: 10.3389/fpsyg.2016.01283. eCollection 2016.

  PMID: 27610095 BACKGROUND

• Keromnes G, Motillon T, Coulon N, Berthoz A, Du Boisgueheneuc F, Wehrmann M, Martin B, Thirioux B, Bonnot O, Ridereau R, Bellissant E, Drapier D, Levoyer D, Jaafari N, Tordjman S. Self-other recognition impairments in individuals with schizophrenia: a new experimental paradigm using a double mirror. NPJ Schizophr. 2018 Nov 28;4(1):24. doi: 10.1038/s41537-018-0065-5.

  PMID: 30487540 BACKGROUND

• Keromnes G, Chokron S, Celume MP, Berthoz A, Botbol M, Canitano R, Du Boisgueheneuc F, Jaafari N, Lavenne-Collot N, Martin B, Motillon T, Thirioux B, Scandurra V, Wehrmann M, Ghanizadeh A, Tordjman S. Exploring Self-Consciousness From Self- and Other-Image Recognition in the Mirror: Concepts and Evaluation. Front Psychol. 2019 May 7;10:719. doi: 10.3389/fpsyg.2019.00719. eCollection 2019.

  PMID: 31133909 BACKGROUND

• Uddin LQ, Davies MS, Scott AA, Zaidel E, Bookheimer SY, Iacoboni M, Dapretto M. Neural basis of self and other representation in autism: an FMRI study of self-face recognition. PLoS One. 2008;3(10):e3526. doi: 10.1371/journal.pone.0003526. Epub 2008 Oct 29.

  PMID: 18958161 BACKGROUND

• Ionta S, Gassert R, Blanke O. Multi-sensory and sensorimotor foundation of bodily self-consciousness - an interdisciplinary approach. Front Psychol. 2011 Dec 23;2:383. doi: 10.3389/fpsyg.2011.00383. eCollection 2011.

  PMID: 22207860 BACKGROUND

• Parnas J, Moller P, Kircher T, Thalbitzer J, Jansson L, Handest P, Zahavi D. EASE: Examination of Anomalous Self-Experience. Psychopathology. 2005 Sep-Oct;38(5):236-58. doi: 10.1159/000088441. Epub 2005 Sep 20. No abstract available.

  PMID: 16179811 BACKGROUND

MeSH Terms

Conditions

Psychotic Disorders; Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Nathalie LAVENNE

  CHRU BREST

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nathalie LAVENNE

CONTACT

02 98 01 50 46; nathalie.lavenne-collot@chu-brest.fr

Nolwenn DISSAUX

CONTACT

06 79 38 11 16; nolwenn.dissaux@chu-brest.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Prospective interventional case / control trial

Study Record Dates

• First Submitted: April 22, 2021
• First Posted: June 30, 2021
• Study Start: May 31, 2022
• Primary Completion (Estimated): July 31, 2027
• Study Completion (Estimated): July 31, 2027
• Last Updated: March 19, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be available after the publication of result and ending fifteen years following the last visit of the last patient
• Access Criteria: Data access requests will be reviewed by the internal committee of Brest University Hospital (UH). Requestors will be required to sign and complete a data access agreement.

Locations

FR (1)