Effect of Antihypertensive Drugs on Glaucoma Patients
1 other identifier
observational
200
1 country
1
Brief Summary
It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. In order to explore whether antihypertensive medications would influence the neuropathy among glaucomatous population, we designed a cross-sectional observational study to analyze the retinal status among glaucoma patients with use of antihypertensive medication.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2021
CompletedFirst Submitted
Initial submission to the registry
June 16, 2021
CompletedFirst Posted
Study publicly available on registry
June 29, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedJune 29, 2021
May 1, 2021
1.6 years
June 16, 2021
June 27, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
retinal nerve fiber layer thickness
retinal nerve fiber layer thickness measured by optical coherence tomography
within 3 months from recruitment
Study Arms (4)
healthy control
adults without glaucoma history or hypertension history
glaucoma patients
adults with primary glaucoma history; without glaucoma-related operation history; without hypertension history
hypertension patients
adults with primary hypertension history; without glaucoma history
glaucoma+hypertension
adults with primary glaucoma history and primary hypertension history; without glaucoma-related operation history
Interventions
no intervention, only measurement of blood pressure, intraocular pressure, hypertensive history questionnaire, retinal imaging, optical coherence tomography examination etc..
Eligibility Criteria
outpatient from ophthalmology and cardiology clinic
You may qualify if:
- age no less than 18 years
- best corrected visual acuity better than decimal 0.3
You may not qualify if:
- secondary glaucoma
- secondary hypertension
- glaucoma-related operation history
- pregnancy or lactation period
- uncooperative with retinal examination
- severe opacity with refracting media in eye
- severe retinal diseases and neuropathy
- congenital retinal optic nerve abnormality
- other systemic diseases that influence hypertension and glaucoma assessment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310000, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kaijun Wang, MD
Second Affiliated Hospital of College of Medicine, Zhejiang University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 16, 2021
First Posted
June 29, 2021
Study Start
May 1, 2021
Primary Completion
December 1, 2022
Study Completion
December 31, 2022
Last Updated
June 29, 2021
Record last verified: 2021-05