NCT04941144

Brief Summary

This study is a long-term follow-up survey of Japanese people after their second vaccination with the Moderna COVID-19 vaccine. The study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. The main aim of the study is to check for long-term side effects of the COVID-19 vaccine. This will be from 28 days to 12 months after the second vaccination of the COVID-19 vaccine. The number of visits to the clinic will depend on the clinic's standard practice.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8,538

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 25, 2021

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 28, 2021

Completed
6 months until next milestone

Study Start

First participant enrolled

December 22, 2021

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 28, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 28, 2023

Completed
Last Updated

May 19, 2023

Status Verified

May 1, 2023

Enrollment Period

1.3 years

First QC Date

June 25, 2021

Last Update Submit

May 17, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants with Serious Adverse Events (SAE)

    An SAE is defined as any untoward medical occurrence that: Results in death, Is life-threatening, Requires in patient hospitalization or prolongation of existing hospitalization, Results in persistent or significant disability/incapacity, Leads to a congenital anomaly/birth defect in the offspring of a participant, or Is an important medical event.

    11 months (From 28 days to 12 months after the second vaccination)

Secondary Outcomes (3)

  • Number of Participants who Take COVID-19 Pathogen (Severe Acute Respiratory Syndrome coronavirus [SARS-CoV-2]) Test during the Study

    11 months (From 28 days to 12 months after the second vaccination)

  • Number of Participants who Developed COVID-19 during the Study

    11 months (From 28 days to 12 months after the second vaccination)

  • Number of Participants Who Have Severe COVID-19 Infection during the Study Evaluated by Investigator

    11 months (From 28 days to 12 months after the second vaccination)

Study Arms (1)

COVID-19 Vaccine Intramuscular Injection 0.5 milliliters (mL)

COVID-19 vaccine intramuscular injection, 2 doses of 0.5 mL per dose administered intramuscularly at an interval of 4 weeks.

Biological: COVID-19 Vaccine

Interventions

COVID-19 Vaccine Intramuscular Injection

Also known as: COVID-19 Vaccine Moderna Intramuscular Injection, Spikevax Intramuscular Injection
COVID-19 Vaccine Intramuscular Injection 0.5 milliliters (mL)

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The population of this survey are vaccinated participants who meet the inclusion/exclusion criteria.

You may qualify if:

  • Participants who have participated in the preceding cohort study and has subsequently provided written consent to participate in this study.

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Moderna selected site

Tokyo, Japan

Location

MeSH Terms

Conditions

COVID-19

Interventions

COVID-19 Vaccines

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Viral VaccinesVaccinesBiological ProductsComplex Mixtures

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 25, 2021

First Posted

June 28, 2021

Study Start

December 22, 2021

Primary Completion

April 28, 2023

Study Completion

April 28, 2023

Last Updated

May 19, 2023

Record last verified: 2023-05

Locations