Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 35/100

Failure Rate

8.0%

11 terminated/withdrawn out of 137 trials

Success Rate

88.0%

+1.5% vs industry average

Late-Stage Pipeline

20%

27 trials in Phase 3/4

Results Transparency

43%

35 of 81 completed trials have results

Key Signals

20 recruiting35 with results7 terminated4 withdrawn

Enrollment Performance

Analytics

Phase 1
58(50.9%)
Phase 2
27(23.7%)
Phase 3
22(19.3%)
Phase 4
5(4.4%)
Early Phase 1
1(0.9%)
N/A
1(0.9%)
114Total
Phase 1(58)
Phase 2(27)
Phase 3(22)
Phase 4(5)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (137)

Showing 20 of 137 trials
NCT05164094Phase 1Active Not Recruiting

A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old Healthy Adolescents and Adults

Role: lead

NCT04899310Phase 1Terminated

A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of mRNA-3705 in Participants With Isolated Methylmalonic Acidemia

Role: lead

NCT04232280Phase 2Completed

Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy Adults

Role: lead

NCT06623422Phase 3Recruiting

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Role: collaborator

NCT07117487Phase 3Completed

A Study of mRNA-1345 Following a Primary Dose of a Licensed Protein Subunit Respiratory Syncytial Virus (RSV) Vaccine in Adult Participants ≥60 Years of Age

Role: lead

NCT06077760Phase 3Recruiting

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Role: collaborator

NCT07561294Phase 2Not Yet Recruiting

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age)

Role: lead

NCT05815498Phase 3Completed

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

Role: lead

NCT07266558Phase 4Active Not Recruiting

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Role: lead

NCT06333704Active Not Recruiting

Post-marketing Surveillance (PMS) Use-Result Surveillance With SPIKEVAX BIVALENT, SPIKEVAX X Injection, SPIKEVAX JN Injection and SPIKEVAX IN PRE-FILLED SYRINGE

Role: lead

NCT07221474Phase 2Recruiting

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

Role: collaborator

NCT07496450Phase 3Recruiting

A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults

Role: lead

NCT06295809Phase 2Completed

A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)

Role: collaborator

NCT06585241Phase 4Recruiting

A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Vaccine Formulations

Role: lead

NCT06833073Phase 2Recruiting

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

Role: collaborator

NCT07478952Phase 1Recruiting

A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189 in Healthy Adults 18 to 30 Years of Age

Role: lead

NCT05992935Phase 1Recruiting

Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1403 and mRNA-1405 to Prevent Norovirus Acute Gastroenteritis in Healthy Adults 18 to 80 Years of Age

Role: lead

NCT05130437Phase 1Recruiting

A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

Role: lead

NCT07116616Phase 1Recruiting

A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

Role: lead

NCT05683457Phase 2Recruiting

A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants.

Role: lead