Resistance Training and Blood Flow Restriction

NCT04938947 | Completed

• 1 other identifier: STUDY00147374
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

The primary purposes of the proposed study is 1) To examine the changes of muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction and 2) To examine changes in motor unit size (a non-invasive measure of muscle fiber size) in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction.

Conditions

Blood Flow Restriction and Low-Intensity Resistance Training

Outcome Measures

Primary Outcomes (2)

• Determine changes in muscle fiber cross-sectional area

  A primary purpose of the study is to examine the changes of muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction

  July 2021-May 2022

• Determine changes in motor unit size

  Another primary purpose of the study is to examine changes in motor unit size (a non-invasive measure of muscle fiber size) in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction

  July 2021- May 2022

Study Arms (2)

High-Intensity Resistance Training Group

EXPERIMENTAL

Participants in this group will complete 3 resistance training sessions per week for 6 weeks (18 sessions total). During each resistance training session, participants will perform 3 sets of bilateral leg-extensions (performed with both legs) to volitional failure (likely 8-12 repetitions) using 80% of their 1-repetition maximum (the most weight they are able to perform 1 complete repetition with, but not 2).

Other: High-Intensity Resistance Training

Low-Intensity Resistance Training with Blood Flow Restriction Group

EXPERIMENTAL

Participants in this group will complete 3 resistance training sessions per week for 6 weeks (18 sessions total). During each training session, participants will perform 3 sets of bilateral leg-extensions (performed with both legs) to volitional failure using 30% of their 1-repetition maximum (the most weight they are able to perform 1 complete repetition with, but not 2). Participants in this group will perform all leg extensions with blood flow restriction cuffs applied to the proximal thigh of both legs. The pressure that the cuffs are inflated to will be calculated based on estimates of each subject's arterial occlusion pressure from their thigh circumference. Once the target pressure is reached, the cuffs will not be deflated until after the final set of the training session.

Device: Blood Flow Restriction Cuffs; Other: Low-Intensity Resistance Training

Interventions

Blood Flow Restriction Cuffs DEVICE

This intervention consists of inflatable cuffs that are designed to partially occlude veinous blood return from the lower extremities during resistance training.

Also known as: Blood Flow Occlusion Cuffs

Low-Intensity Resistance Training with Blood Flow Restriction Group

Low-Intensity Resistance Training OTHER

This intervention consists of performing low-intensity bilateral (both legs at the same time) leg extensions using 30% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.

Low-Intensity Resistance Training with Blood Flow Restriction Group

High-Intensity Resistance Training OTHER

This intervention consists of performing high-intensity bilateral (both legs at the same time) leg extensions using 80% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.

High-Intensity Resistance Training Group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• Participants must not have participated in resistance training more than 5 times in the 6 months preceding the study.
• Participants must be healthy and free of any cardiovascular, metabolic or musculoskeletal conditions that may affect the results of the investigation.
• Participants must not have a history of severe hip, knee and/or ankle injuries, or any other pathological conditions that impair their motor control.
• Participants must not have any pre-existing cardiovascular conditions that involve blood flow/blood clotting.
• Participants who are currently taking blood thinners or any medications regulating blood pressures or heart rate will not be eligible to participate in the study.
• Female participants who are pregnant at the start of or who are planning to become pregnant during the resistance training intervention will not be eligible to participate in the study.

Sponsors & Collaborators

• University of Kansas: lead

Study Sites (1)

Robinson Center

Lawrence, Kansas, 66045, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Graduate Teaching Assistant

Study Record Dates

• First Submitted: June 22, 2021
• First Posted: June 25, 2021
• Study Start: September 22, 2021
• Primary Completion: February 15, 2022
• Study Completion: February 15, 2022
• Last Updated: November 1, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)