COVID-19 - SARS-CoV-2 Community Contamination in Children and Adults - Impact of Variants (Dyn3CEA - Nosocor Phase 2)

NCT04924842 | Completed

• 1 other identifier: 69HCL21_0564
• Study Type: observational
• Target: 87
• Locations: 1 country
• Sites: 1

Brief Summary

Unlike other respiratory viruses such as influenza and RSV where the child is the essential reservoir and central vector of intrafamilial contamination, the child is likely to be a small player in the transmission of CoV2-CoRSA infection. This study aims to describe the age category of the first contact, within 14 days before the appearance of the first symptoms of the index case in order to describe the age categories of this first contaminant, globally, in the group of children and finally in the group of adults. This work is intended to provide food for discussion and to justify the distancing and containment measures imposed on children when their isolation has a deleterious impact that has now been established for some children.

Conditions

Infection Viral

Outcome Measures

Primary Outcomes (1)

• Percentage of possible contaminants, adults, adolescents and children with Covid-19

  To describe the age category of the 1st possible contaminant in the index case to show the preponderance of possible adult and adolescent contaminants in the SARS-Cov-2 contamination. Primary endpoint: Percentage of possible contaminants, adults, adolescents and children, in matched children and adults with Covid-19.

  At inclusion

Study Arms (2)

Children

Hospitalized children, 0 to 17 years of age, 30 subjects, consecutive sample survey, recruitment in quotas of five age ranges.

Other: Review of medical file

Adults

Hospitalized adults, 18 years and above, 60 matched subjects

Other: Phone call interview

Interventions

Review of medical file OTHER

Review of medical patient file, including patient tracing, brief summary of the disease course, barrier gestures, social distancing.

Children

Phone call interview OTHER

less than 15 minutes phone call

Adults

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospital-based population of children and adults: * Hospitalized children, 0 to 17 years of age, 25 subjects, consecutive sample survey * Hospitalized adults, 18 years and above, 50 matched subjects

You may qualify if:

• \) Children hospitalized in the Pediatric department of the Hospices Civils de Lyon with PCR positive for a variant of the historical SARS-CoV2, 2) Adults hospitalized in the the Hospices Civils de Lyon, for a Covid-19 disease with documented infection by a variant of the SARS-CoV-2 and included in the NOSO-COR study with matching criteria described below.

You may not qualify if:

• Any patient suspected of nosocomial infection.
• Any patient death during the Covid-19 infection.
• Any adult patient without children living home.
• Opposition to participate.

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital Femme Mère et enfant

Lyon, Auvergne-Rhône-Alpes, 69003, France

Location

MeSH Terms

Conditions

Virus Diseases

Condition Hierarchy (Ancestors)

Infections

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2021
• First Posted: June 14, 2021
• Study Start: June 22, 2021
• Primary Completion: October 28, 2021
• Study Completion: October 28, 2021
• Last Updated: January 4, 2022

Record last verified: 2022-01

Locations

FR (1)