Detection of Acute Renal Failure Using Hospital Coding Data

NCT04923750 | Completed

• 1 other identifier: PI2020_843_0018
• Study Type: observational
• Target: 498
• Locations: 1 country
• Sites: 1

Brief Summary

AKI is a rapid and usually reversible impairment of kidney function that is life-threatening in the short term well described by the "Kidney Disease: Improving Global Outcomes - KDIGO" classification of 2012. Whatever etiology of acute renal failure, drug iatrogeny still has its place. Hospital data from the information systems medicalization program (PMSI) can be used for epidemiological research. No study has yet been performed on these data to assess drug-related AKI. However, it should be remembered that these databases were not originally designed for research purposes but for reimbursement of care. Therefore, before conducting a large-scale study, it remains important to determine the validity and representativeness of the codes used for coding the studied events. The objective of this project is therefore to validate the use of hospital coding to identify AKI.

Conditions

Acute Renal Failure; Iatrogenic Effect; Uremic Toxin

Keywords

acute renal failure; iatrogenic; pharmaco epidemiology; medico economy; Uremic toxin; PMSI

Outcome Measures

Primary Outcomes (2)

• identification of AKIs by codes in the PMSI database

  two years

• identification of drug-induced AKIs by codes in the PMSI database

  two years

Secondary Outcomes (6)

• Variation of performance of the codes according to the characteristics of the AKI

  two years

• Variation of performance of the codes according to KDIGO grade

  two years

• Variation of performance of the codes according to hospitalization service

  two years

• Identification of the type of drugs involved in drug-induced AKI

  two years

• incidence of drug-induced AKI

  two years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized at the CHU Amiens Picardie during 6 months and for which at least two plasma creatinine measurements were taken during the hospitalization

You may qualify if:

• Patients over \> = 18 years old
• Patients hospitalized at the CHU Amiens Picardie during 6 months
• patients for which at least two plasma creatinine measurements were taken during the hospitalization

You may not qualify if:

• Patients under \<18 years old
• Patients on dialysis for chronic renal failure
• Hospitalization for a kidney transplant
• Postpartum AKI

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80480, France

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 7, 2021
• First Posted: June 11, 2021
• Study Start: June 3, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: July 3, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)