Study of the Evolution Profile of the Renal Doppler in the Perioperative Hepathic Transplantation

NCT04682236 | Unknown

• 1 other identifier: 8059
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Liver transplantation is associated with a modification of the perfusion pressures of the abdominal organs (preoperative portal hypertension in connection with liver pathology, and normalization of the perfusion pressures during surgery). This abrupt change in the infusion regime is probably responsible for an alteration in renal function in some patients, and the identification of renal vascular profiles using Doppler could point to pathological profiles, which should be diagnosed early.

Conditions

Acute Renal Failure

Keywords

Acute Renal Failure; Chronic renal failure; Liver transplant; Renal vascular profiles; Intraoperative hemodynamic instability; Acute tubular necrosis; Renal doppler

Outcome Measures

Primary Outcomes (1)

• Retrospective analysis of the development profiles of renal dopplers in perioperative liver transplantation

  Files analysed retrospectily from July 1st, 2019 to June 30, 2020 will be examined

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patient operated on at the HUS for a liver transplant, between July 1, 2019 and June 30, 2020

You may qualify if:

• Patient of full age (≥18 years)
• Patient operated on at the HUS for a liver transplant, between July 1, 2019 and June 30, 2020.
• Patients having undergone an evaluation of hepatic and renal vascular profiles perioperatively.
• Patients hospitalized in the surgical intensive care unit after hepatic transplant surgery.
• Patient not having expressed, after information, the reuse of his data for the purposes of this research

You may not qualify if:

• Patient who expressed his opposition to participating in the study
• Patient with suspected obstructive acute renal failure
• Stenosis of renal arteries known at the time
• End-stage renal disease on dialysis
• Impossibility of giving the subject informed information (difficulties in understanding the subject, etc.)
• Subject under safeguard of justice

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Strasbourg University Hospitals - Anesthesia-intensive care unit

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Acute Kidney Injury; Kidney Failure, Chronic; Kidney Cortex Necrosis

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Renal Insufficiency, Chronic; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Julien POTTECHER, MD, PhD

  Strasbourg University Hospitals - Anesthesia-intensive care unit

  STUDY DIRECTOR

Central Study Contacts

Julien POTTECHER, MD, PhD

CONTACT

33 3 88 12 70 95; julien.pottecher@chru-strasbourg.fr

Saïd CHAYER, PhD, HDR

CONTACT

33 3 88 11 66 90; said.chayer@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2020
• First Posted: December 23, 2020
• Study Start: November 25, 2020
• Primary Completion: May 25, 2022
• Study Completion: May 25, 2022
• Last Updated: December 28, 2020

Record last verified: 2020-12

Locations

FR (1)