Compression Ultrasonography in Non-high Probability of Deep Vein Thrombosis
EPREVUP
Evaluation of the Predictive Value of Compression Venous Ultrasound by the Emergency Physician for Excluding the Diagnosis of Proximal Deep Vein Thrombosis (DVT) in Patients With Non-high Clinical Pretest Probability
1 other identifier
interventional
700
1 country
1
Brief Summary
Compression ultrasound is commonly used in emergency department. Accuracy to rule out deep vein thrombosis is excellent but lower then Ddimer assessment which is actually gold standard. With progress in formation of emergency physicians (EP), quality of material used, the investigators hypothesize that compression ultrasound can rule out deep vein thrombosis in case of non high probability, as standard care and DDimer assay.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2022
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 1, 2021
CompletedFirst Posted
Study publicly available on registry
June 8, 2021
CompletedStudy Start
First participant enrolled
February 21, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 28, 2027
August 3, 2025
August 1, 2025
5 years
June 1, 2021
August 1, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Negative predictive value of compression ultrasound for diagnosis of deep vein thrombosis
The measurement is assessed during ED stay or in 5 days if DD is positive with no DVT in compression ultrasound
Study Arms (1)
Patient with clinical suspicion of deep vein thrombosis
EXPERIMENTALInterventions
performing a compression ultrasound
Eligibility Criteria
You may qualify if:
- adult patient
- Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema).
- Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1
- Subject with a social health insurance plan
- Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent
You may not qualify if:
- Patient with suspected pulmonary embolism
- Patient with a high probability of DVT
- Impossible to perform a whole leg doppler ultrasound within 5 days
- Pregnant or breast-feeding woman, on patient's declaration
- Subject under court protection
- Subject under guardianship or curatorship
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Strasbourg
Strasbourg, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 1, 2021
First Posted
June 8, 2021
Study Start
February 21, 2022
Primary Completion (Estimated)
February 28, 2027
Study Completion (Estimated)
February 28, 2027
Last Updated
August 3, 2025
Record last verified: 2025-08