NCT04912960|Recruiting
PEEP in Patients With Acute Respiratory Failure
Application of PEEP in Patients With Acute Respiratory Failure Caused by Lung Injury: Assessment of Clinical Practice
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Application of PEEP in Patients With Acute Respiratory Failure Caused by Lung Injury: Assessment of Clinical Practice
Sponsor study identifier
observational
15
1 country
3
Study Start
June 10, 2021
Actual (reported)Primary Completion
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects of PEEP in 15 mechanically ventilated patients with acute respiratory failure (ARF) supported by mechanical ventilation. FiO2 ranged between 21% to 75% and the tidal volume between 13 to 15 mL/kg. PEEP was increased in 3 cmH2O steps until cardiac output fell. The aim was to identify the "optimum" PEEP level. "Best" PEEP was associated simultaneously with the best static compliance of the respiratory system, the greatest oxygen transport, and the lowest dead space fraction. That study established the basis for the use of PEEP in patients with ARF worldwide. Although currently patients with ARF are ventilated with much lower tidal volumes, that study has never been validated. It is unknow whether their findings are currently valid, generalizable, and reproducible.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 24, 2021
Actual (reported)June 3, 2021
Actual (reported)June 10, 2021
Actual (reported)December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
static compliance of the respiratory system
ratio of tidal volume to pressure gradiente of the respiratory system
at study enrollment
oxygen transport
Cardiac output multiply by oxygen content in arterial blood
at study enrollment
dead space fraction
ratio of dead space to tidal volume
at study enrollment
Optimum PEEP
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Mechanically ventilated patients with hypoxemic respiratory failure (PaO2/FiO2 \<300 on FiO2 equal or greater than 0.3)
Hospital Universitario Dr. Negrin
Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
Hospital Clinic
Suter PM, Fairley B, Isenberg MD. Optimum end-expiratory airway pressure in patients with acute pulmonary failure. N Engl J Med. 1975 Feb 6;292(6):284-9. doi: 10.1056/NEJM197502062920604.
Acute Respiratory Distress Syndrome Network; Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1301-8. doi: 10.1056/NEJM200005043421801.
Jesús Villar, MD
Hospital Universitario Dr. Negrin
First Submitted
May 24, 2021
First Posted
June 3, 2021
Study Start
June 10, 2021
Actual (reported)Primary Completion
December 31, 2025
Estimated (date passed)Assessment of PaO2/FiO2 Ratio Pre and POst INTubation
Contact the study team to confirm eligibility.
Barcelona, Spain
Hospital Universitario La Princesa
Madrid, Spain
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 20, 2025
Record last verified: 2025-04
data collection will be shared with all study investigators
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