Hangzhou Hospital Staff Cohort

NCT04910321 | Withdrawn

• 1 other identifier: 20201221ZJS001
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The Hangzhou Hospital Staff Cohort (HHSC) is a prospective cohort study among staffs from three hospitals located in Hangzhou, China, including the Hangzhou First People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital. Participants recruitment and baseline survey including anthropometric, lifestyle and clinical measurement, as well as biological samples collection are initiated in January 2021. Recruited hospital staff are followed up every year during the medical examination organized by their employer. The primary aim of the HHSC study is to investigate the prospective associations of diet, physical activities, sleep, and other lifestyle factors with the long-term metabolic health of the hospital staffs. The secondary aim of the HHSC study is to integrate multi-omics data including genomics, metabolomics, proteomics and microbiome by a machine learning algorithm, to probe into the complex mediating roles of gene, metabolism and gut microbiota linking lifestyle factors with metabolic health.

Conditions

Diabetes Mellitus; Cardiovascular Diseases; Metabolic Syndrome

Outcome Measures

Primary Outcomes (3)

• Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L

  Fasting blood glucose is measured every year during follow-up

  3 years after enrollment

• Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L

  Fasting blood glucose is measured every year during follow-up

  6 years after enrollment

• Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L

  Fasting blood glucose is measured every year during follow-up

  9 years after enrollment

Secondary Outcomes (3)

• Change of body mass index

  Change from baseline at 3 years

• Change of body mass index

  Change from baseline at 6 years

• Change of body mass index

  Change from baseline at 9 years

Interventions

diet, physical activities, sleep OTHER

lifestyle factors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are serving staffs from the Hangzhou Frirst People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital are recruited.

You may qualify if:

• Participants aged 18 years or older
• Serving staffs of designated hospitals

You may not qualify if:

• Participants with cancer
• Participants with other serious medical disorders

Sponsors & Collaborators

• Westlake University: lead
• First People's Hospital of Hangzhou: collaborator
• Hangzhou Women's Hospital: collaborator
• Red Cross Hospital, Hangzhou, China: collaborator

Study Sites (1)

Hangzhou First People's Hospital

Hangzhou, Zhejiang, 310058, China

Location

MeSH Terms

Conditions

Diabetes Mellitus; Cardiovascular Diseases; Metabolic Syndrome

Interventions

Diet; Exercise; Sleep

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Insulin Resistance; Hyperinsulinism

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Nervous System Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 9 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2021
• First Posted: June 2, 2021
• Study Start: December 30, 2020
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: June 13, 2025

Record last verified: 2025-05

Locations

CN (1)