Effect of Ketamine Assisted Analgesia on Oxygen Supply and Oxygen Consumption in Patients After Cardiac Surgery

NCT04906915 | Unknown DMC

• 1 other identifier: ketamine
• Study Type: interventional
• Target: 112
• Locations: 1 country
• Sites: 1

Brief Summary

After cardiopulmonary bypass heart surgery, with the rewarming of body temperature, the metabolic capacity of the body is enhanced, the microcirculation is opened, and tissue perfusion is increased. At the same time, the body pays off the oxygen debt formed by the low temperature and reduced blood flow in cardiopulmonary bypass, so that the tissue oxygen demand increases and oxygen consumption increases.Analgesia and sedation are important treatment measures for patients after cardiopulmonary bypass. S-isomer of ketamine and eselamine enhanced the sedation and enhanced the analgesic effect, but whether it can improve the imbalance of oxygen supply and oxygen consumption after cardiopulmonary bypass is unknown.

Conditions

Intensive Care Unit

Keywords

Ketamine; Extracorporeal circulation; Oxygen Supply; Oxygen Consumption

Outcome Measures

Primary Outcomes (1)

• Oxygen Supply and Oxygen Consumption

  After the patient was admitted to ICU, femoral artery puncture and catheterization were performed to establish PICCO connection access. At 0h, 4h, 8h, 12h, 16h, 20h, 24h, 32h, 40h and 48h after surgery, ice saline injection was used to measure CO, and central vein and peripheral blood samples were collected for blood gas examination.According to the formula, the patient's oxygen supply and oxygen consumption were calculated: DO2=CO×CaO2×10;CaO2 = 1.34 \* SaO2 + 0.003 \* Hb PaO2;VO2 = CI x (CaO2 - CvO2).

  0-48 hours

Study Arms (1)

Ketamine

EXPERIMENTAL

The experimental group was continuously pumped with remifentanil + ketamine for analgesia, and the control group was continuously pumped with remifentanil + placebo (normal saline) for analgesia. RASS and CPOT scores were performed to evaluate the pain degree of the patients.

Drug: Ketamine

Interventions

Ketamine DRUG

The efficacy of ketamine was assessed by calculating oxygen supply and consumption

Ketamine

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Consecutive adult (\>18years)patients after heart surgery

You may not qualify if:

• Chronic kidney disease (CKD); ECMO or IABP assistance is required; Malignant tumor; Acquired immunodeficiency syndrome; receive psychiatric medication.

Sponsors & Collaborators

• First People's Hospital of Chenzhou: lead

Study Sites (1)

First Hospital Chenzhou

Chenzhou, Hunan, 450003, China

RECRUITING

MeSH Terms

Interventions

Ketamine

Intervention Hierarchy (Ancestors)

Cyclohexanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals

Study Officials

• Dixian DX Luo, MS

  Chenzhou First People Hospital

  STUDY DIRECTOR

Central Study Contacts

Mei XM Mei

CONTACT

86-17742594539; 17742594539@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Critical Care Medicine

Study Record Dates

• First Submitted: May 25, 2021
• First Posted: May 28, 2021
• Study Start: May 8, 2021
• Primary Completion: May 1, 2022
• Study Completion: May 1, 2022
• Last Updated: May 28, 2021

Record last verified: 2021-05

Locations

CN (1)