Gonadal Changes In Congenital Adrenal Hyperplasia Patients

NCT04903587 | Unknown

• 1 other identifier: US and MRI in CAH patients
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

To detect the prevalence of gonadal changes by US among the patients with CAH.

• assess the patients' radiological findings in relation to their hormonal profile.
• early management and prevention of complications resulting from possible gonadal dysfunction.

Conditions

Congenital Adrenal Hyperplasia

Outcome Measures

Primary Outcomes (1)

• prevalence of gonadal changes in CAH patients

  By using US and MRI to detect the finding in gonades in CAH patients

  baseline

Interventions

Ultrasonography and MRI DEVICE

Abdominal Ultrasonography and axial MRI

Eligibility Criteria

• Age: 5 Years - 16 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

all patients diagnosed with congenital adrenal hyperplasia (CAH)

You may qualify if:

• All patients diagnosed with CAH between five and 16 years of age will be asked to participate in this cross sectional study.
• Compliant patients with regular follow up.

You may not qualify if:

• Presence of other endocrinal diseases or chronic conditions.
• Female patients with ovulatory dysfunction from other causes including thyroid dysfunction and hyperprolactinemia.
• Male patients with other diseases causing impairment of gonadal capacity.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Egypt

RECRUITING

Related Publications (2)

• Dumic M, Duspara V, Grubic Z, Oguic SK, Skrabic V, Kusec V. Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients. Eur J Pediatr. 2017 Oct;176(10):1393-1404. doi: 10.1007/s00431-017-3008-7. Epub 2017 Sep 6.

  PMID: 28879515 BACKGROUND

• Chen HD, Huang LE, Zhong ZH, Su Z, Jiang H, Zeng J, Liu JC. Ovarian Adrenal Rest Tumors Undetected by Imaging Studies and Identified at Surgery in Three Females with Congenital Adrenal Hyperplasia Unresponsive to Increased Hormone Therapy Dosage. Endocr Pathol. 2017 Jun;28(2):146-151. doi: 10.1007/s12022-016-9461-4.

  PMID: 28032206 BACKGROUND

MeSH Terms

Conditions

Adrenal Hyperplasia, Congenital

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Adrenogenital Syndrome; Disorders of Sex Development; Urogenital Abnormalities; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn; Steroid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Metabolic Diseases; Nutritional and Metabolic Diseases; Adrenal Gland Diseases; Endocrine System Diseases; Gonadal Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Central Study Contacts

Hasnaa Hassan, post gradute

CONTACT

01000748134; dr.hmm28@gmail.com

Mohamed Salah Elkholy, professor

CONTACT

01005838888

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 23, 2021
• First Posted: May 26, 2021
• Study Start: October 1, 2021
• Primary Completion: October 1, 2022
• Study Completion: November 1, 2022
• Last Updated: December 30, 2021

Record last verified: 2021-05

Locations

EG (1)