Brain Exercise and Addiction Trial

You may not qualify if:

• Have a history of cardiovascular disease, high blood pressure, musculoskeletal injury or other condition that would preclude safe engagement in VO2 max fitness testing and/or regular physical exercise
• Severe claustrophobia, non-MR compatible metallic implant, or other contraindication to MRI scanning
• Lifetime history of significant neurological illness, or moderate - severe brain injury,
• Current major unstable medical illness or chronic pain condition
• Lifetime history of schizophrenia, schizoaffective disorder, OCD, PTSD, bipolar disorder
• Current significant depression or anxiety that precludes ability to reliably engage in the exercise program
• Current moderate - severe substance use disorder for substances other than cannabis (excluding nicotine)
• Currently pregnant or lactating
• Shift work employment schedule within the prior 6-months
• Have engaged in ≥5 sessions of HITT or resistance training within the past 12-months
• History of treatment with antipsychotic medications
• Current participation in psychosocial treatment for substance use disorder
• Other psychoactive medications or psychosocial treatments will be considered on a case-by-case basis. Where a current psychoactive medication is deemed acceptable, both dose and type must have been stable for a minimum of four weeks prior to baseline assessment, and remain stable throughout the 12-week exercise phase of the study.