Active Older Adult Program on Health and Well-being
The Effects of an Active Older Adult Program at the Dan Abraham Healthy Living Center on Health and Well-being
1 other identifier
observational
33
1 country
1
Brief Summary
The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 7, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 2, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
April 2, 2020
CompletedFirst Submitted
Initial submission to the registry
May 17, 2021
CompletedFirst Posted
Study publicly available on registry
May 21, 2021
CompletedMay 21, 2021
May 1, 2021
1.7 years
May 17, 2021
May 19, 2021
Conditions
Outcome Measures
Primary Outcomes (3)
Change in repeated chair rise time
Chair stand test where participants will perform a chair rise movement for five repetitions. The series of 5 repetitions will be timed and measured in seconds.
Baseline to end of study, approximately 14 weeks
Change in plasma protein levels reflective of biological age
Blood samples will be obtained at baseline and at 12 weeks. The concentration of target proteins (pg/mL) in the plasma will be measured and compared between baseline and week 12.
Baseline, week 12
Change in expression of senescence-related genes in blood cells
Blood samples will be obtained at baseline and at 12 weeks. The expression of senescence-related genes (arbitrary units) will be measured in immune cells isolated from whole blood and compared between baseline and week 12.
Baseline, week 12
Secondary Outcomes (4)
Change in Self-reported Physical Function
Baseline, week 12
Change in Performance-based Physical Function
Baseline, week 12
Change in Mental Function
Baseline, week 12
Change in self-assessment of well-being
Baseline, week 12
Eligibility Criteria
The target population consists of The Dan Abraham Healthy Living Center (DAHLC) members 60 years of age and older who plan to participate in the Active Older Adult Program.
You may qualify if:
- Men and women age 55 years or older.
- Membership at the DAHLC.
- New to AOA (Active Older Adult) Program and commitment to full participation in the twelve-week program.
- Must be able to get down and off the floor with little assistance.
You may not qualify if:
- Inability to provide informed consent.
- Previous participation in the AOA Program at the DAHLC.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
Related Links
Biospecimen
Blood-derived plasma and CD3+ T-cells
Study Officials
- PRINCIPAL INVESTIGATOR
Nathan LeBrasseur, PhD, MS
Mayo Clinic
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 17, 2021
First Posted
May 21, 2021
Study Start
August 7, 2018
Primary Completion
April 2, 2020
Study Completion
April 2, 2020
Last Updated
May 21, 2021
Record last verified: 2021-05