Assessment of Inflammation With Haematological Parameters in Patients With Migraine and Tension Type Headache: a Prospective Study From a Tertiary Care Center
Sponsor study identifier
observational
230
1 country
1
Study Start
May 1, 2018
Actual (reported)Primary Completion
May 31, 2019
Actual (reported)Study Completion
May 31, 2019
Actual (reported)Headache is the most common neurological complaint accounting for % 1 to % 4 in the emergency department (ED).Every year, nearly one million people with headache attacks have been consulted by healthcare professionals at the emergency room in the United States.The International Classification of Headache Disorders (ICHD) divided headaches into two main groups: primary headaches and secondary headaches. The vast majority of cases who presented with acute headache attack in ED had a diagnosis of primary headache disorders (tension- type headache, migraine, cluster- type headache, and other primary headaches). However, secondary headache is often associated with underlying intracranial pathologies, and noted in % 10 of cases in emergency rooms. Despite the frequent presence of primary headaches, limited time setting and busy periods of medical assessment, leading diagnostic and therapeutic options due to the pathophysiological factors to be overlooked. To date, no study in the emergency care setting has explored the role of inflammation in patients with acute migraine and TTH. Investigators aimed to explore inflammatory markers \[white blood cells (WBC), neutrophil, lymphocyte, platelet, neutrophil / lymphocyte ratio (NLR), and platelet / lymphocyte ratio (PLR)\] in complete blood count (CBC) among MA, MO, and TTH participants who admitted to ED with acute headache attack and healthy volunteers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 31, 2019
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1, 2018
Actual (reported)May 31, 2019
Actual (reported)May 31, 2019
Actual (reported)April 20, 2021
Actual (reported)May 19, 2021
Actual (reported)White blood cells
White blood cells (x10³/μL) counted in complete blood count and compared between patients and healthy controls
Up to 1 year
Neutrophil
Neutrophil (x10³/μL) levels counted in complete blood count and compared between patients and healthy controls
Up to 1 year
Lymphocyte
Lymphocyte (x10³/μL) levels counted in complete blood count and compared between patients and healthy controls
Up to 1 year
Platelet
Platelet (x10³/μL) levels counted in complete blood count and compared between patients and healthy controls
Up to 1 year
51 patients with MA
51 patients with migraine without aura
48 patients with tension type headache
80 healthy participants
inflammatory values in complete blood count (CBC)
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Migraine and tension-type headache patients who admitted to emergency department with an acute headache attack
Halil Okay Albayrak
Kocaeli, İzmit, 41100, Turkey (Türkiye)
Albayrak HO, Gurbuz H, Basaran S, Yilmaz S. Assessment of inflammation with hematological parameters in patients with migraine and tension-type headache: a prospective study from a tertiary care center. Pain Manag. 2022 Mar;12(2):141-148. doi: 10.2217/pmt-2021-0036. Epub 2021 Aug 25.
Serkan Yılmaz, Prof
Kocaeli University Department of Emergency Medicine
Serkan Yılmaz, Prof
Kocaeli University Department of Emergency Medicine
230 participants (actual enrollment reported by the registry).
First Submitted
April 20, 2021
First Posted
May 19, 2021
Study Start
May 1, 2018
Actual (reported)Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
Neutrophil/lymphocyte ratio
Neutrophil/lymphocyte ratio calculated by dividing absolute neutrophil to absolute lymphocyte and compared between patients and healthy controls.
Up to 1 year
Platelet/lymphocyte ratio
Platelet/lymphocyte ratio calculated by dividing absolute platelet to absolute lymphocyte and compared between patients and healthy controls.
Up to 1 year
Contact the study team to confirm eligibility.
Primary Completion
May 31, 2019
Actual (reported)Study Completion
May 31, 2019
Actual (reported)Last Updated
May 19, 2021
Record last verified: 2021-05
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Source: ClinicalTrials.gov.
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