The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

NCT04891146 | Completed

• 1 other identifier: AbdurrahmanYAOTRH
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.

Conditions

Systemic Immune Activation; Cancer Gi; Cancer of Endometrium

Outcome Measures

Primary Outcomes (1)

• investigate the effect of anesthesia management on the change of preoperative systemic inflammatory immune index(SII) and postoperative 2.hour and 24.hour SII value

  systemic inflammatory immune index calculated by (platelet x neutrophil)/lymphocyte

  preoperative SII noted, postoperative 2.hour noted and postoperative 24.hour noted

Study Arms (2)

Inhalation anesthesia

Sevoflurane for opioid remifentanyl used

Other: Systemic inflammatory immmune index

Total Intravenous Anesthesia

Propofol for opioid remifentanyl used

Other: Systemic inflammatory immmune index

Interventions

Systemic inflammatory immmune index OTHER

Systemic Inflammatory Immune index calculated from platelet, neutrophil and lymphocyte count

Inhalation anesthesia; Total Intravenous Anesthesia

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

major abdominal cancer patients between 18-85 years included. 40 patients in sevoflurane group and 44 patients in TIVA group collected

You may qualify if:

• major abdominal cancer surgeries

You may not qualify if:

• blood transfusion in last 72 hours
• patients with infection
• hematologic malignancy
• patient controlled analgesia

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Oncology Research and Trainee Hospital

Ankara, Yenimahalle, 06200, Turkey (Türkiye)

Location

Related Publications (2)

• Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, Zhang X, Wang WM, Qiu SJ, Zhou J, Fan J. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442. Epub 2014 Sep 30.

  PMID: 25271081 RESULT

• Lee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean J Anesthesiol. 2016 Apr;69(2):126-32. doi: 10.4097/kjae.2016.69.2.126. Epub 2016 Mar 30.

  PMID: 27066202 RESULT

MeSH Terms

Conditions

Gastrointestinal Neoplasms; Endometrial Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Arsen Gungor

  arsen.gungor@hotmail.com

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation Specialist

Study Record Dates

• First Submitted: March 17, 2021
• First Posted: May 18, 2021
• Study Start: March 5, 2020
• Primary Completion: September 15, 2020
• Study Completion: December 12, 2020
• Last Updated: May 18, 2021

Record last verified: 2021-03

Locations

TU (1)