NCT04888585

Brief Summary

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluated how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity were assessed. ABBV-154 is an investigational drug being evaluated for the treatment of RA. Study doctors placed the participants in 1 of 5 treatment groups or arms; each arm received a different treatment. There was a 1 in 5 chance that participants were assigned to placebo. Participants 18-75 years of age with moderate to severe RA were enrolled. Around 425 participants were to be enrolled in the study at approximately 270 sites worldwide. The study was comprised of a 12 week placebo-controlled period, a double-blind long term extension (LTE) period 1 of 66 weeks, a LTE period 2 of 104 weeks and a follow-up visit 70 days after the last dose of the study drug. In the LTE period 1, participants in the placebo group were re-randomized to receive ABBV-154 at 1 of 2 different doses SC every other week (EOW). Other participants remained on their previous dose and dosing regimen of ABBV-154. There may have been a higher treatment burden for participants in this trial compared to their standard of care. Participants attended regular visits during the study at a hospital or clinic. The effect of the treatment was checked by medical assessments, blood tests, and side effects, and completing questionnaires.

Trial Health

68
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
473

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jun 2021

Geographic Reach
21 countries

220 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 13, 2021

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 17, 2021

Completed
1 month until next milestone

Study Start

First participant enrolled

June 23, 2021

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 25, 2022

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 4, 2023

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

October 8, 2024

Completed
Last Updated

October 8, 2024

Status Verified

September 1, 2024

Enrollment Period

1.2 years

First QC Date

May 13, 2021

Results QC Date

August 19, 2024

Last Update Submit

September 30, 2024

Conditions

Keywords

Rheumatoid Arthritis (RA)ABBV-154AIM-RA

Outcome Measures

Primary Outcomes (1)

  • Achievement of 50% Improvement as Measured by American College of Rheumatology Response Criteria (ACR50) at Week 12

    Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR50 response criteria: 1. ≥ 50% improvement in 68-tender joint count; 2. ≥ 50% improvement in 66-swollen joint count; and 3. ≥ 50% improvement in at least 3 of the 5 following parameters: * Physician's Global Assessment of Disease Activity (NRS) * Patient's Global Assessment of Disease Activity (NRS) * Patient's Assessment of Pain (NRS) * Health Assessment Questionnaire - Disability Index (HAQ-DI) * High-sensitivity C-reactive protein (hsCRP).

    Week 12

Secondary Outcomes (9)

  • Change From Baseline in Disease Activity Score (DAS) 28 (CRP) at Week 12

    Baseline to Week 12

  • Change in Clinical Disease Activity Index (CDAI) at Week 12

    Baseline to Week 12

  • Percentage of Participants Achieving American College of Rheumatology 20% (ACR20) Response at Week 12

    Week 12

  • Percentage of Participants Achieving American College of Rheumatology 70% (ACR70) Response at Week 12

    Week 12

  • Percentage of Participants Achieving Low Disease Activity (LDA) Defined by DAS28 (CRP) <= 3.2 at Week 12

    Week 12

  • +4 more secondary outcomes

Study Arms (5)

Dose A of ABBV-154

EXPERIMENTAL

Participants in this group will receive dose A of ABBV-154 subcutaneously (SC) every other week (eow) for 12 weeks in the placebo-controlled period, 66 weeks in the long term extension (LTE) period 1 and 104 weeks in LTE period 2.

Drug: ABBV-154

Dose B of ABBV-154

EXPERIMENTAL

Participants in this group will receive dose B of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2.

Drug: ABBV-154

Dose C of ABBV-154 EOW

EXPERIMENTAL

Participants in this group will receive dose C of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2.

Drug: ABBV-154

Dose C of ABBV-154 E4W

EXPERIMENTAL

Participants in this group will receive dose C of ABBV-154 SC every 4 weeks (e4w) for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2.

Drug: ABBV-154

Placebo

EXPERIMENTAL

Participants in this group will receive placebo SC eow for 12 weeks in the placebo-controlled period and will be re-randomized in 1:1 ratio to receive ABBV-154 dose B or C respectively SC eow for 66 weeks in the LTE period 1 and 104 weeks in LTE period 2.

Drug: ABBV-154Drug: Placebo

Interventions

Subcutaneous Injection

Dose A of ABBV-154Dose B of ABBV-154Dose C of ABBV-154 E4WDose C of ABBV-154 EOWPlacebo

Subcutaneous Injection

Placebo

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Clinical diagnosis of rheumatoid arthritis(RA) with fulfillment of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for RA.
  • Participant has \>= 6 swollen joints (based on 66 joint count) and \>=6 tender joints (based on 68 joint count) at baseline.
  • Participant must have had an inadequate response to at least one prior biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) treatment for RA.
  • Participants must be on stable dose of methotrexate (MTX).

You may not qualify if:

  • \- Participant discontinued prior adalimumab therapy due to intolerability or toxicity.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (220)

Elite Clinical Studies, LLC /ID# 228227

Phoenix, Arizona, 85018, United States

Location

Arthritis and Rheumatism Associates /ID# 228201

Jonesboro, Arkansas, 72401-6251, United States

Location

Providence Medical Foundation /ID# 228104

Fullerton, California, 92835, United States

Location

Care Access Research, Huntington Beach /ID# 228163

Huntington Beach, California, 92648, United States

Location

Purushotham & Akther Kotha MD, Inc /ID# 228120

La Mesa, California, 91942, United States

Location

Arthritis & Osteo Medical Ctr /ID# 228239

La Palma, California, 90623-1728, United States

Location

Pacific Arthritis Care Center - Los Angeles /ID# 229330

Los Angeles, California, 90045-6200, United States

Location

California Medical Research Associates /ID# 230131

Northridge, California, 91324, United States

Location

Arthritis Care And Research Center ACRC /ID# 230099

Poway, California, 92064, United States

Location

East Bay Rheumatology Medical /ID# 228099

San Leandro, California, 94578, United States

Location

Millennium Clinical Trials /ID# 230618

Thousand Oaks, California, 91360-3951, United States

Location

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 228241

Torrance, California, 90502, United States

Location

Medvin Clinical Research /ID# 228181

Tujunga, California, 91042-2706, United States

Location

Inland Rheum & Osteo Med Grp /ID# 228204

Upland, California, 91786, United States

Location

Comprehensive Rheumatology Center /ID# 230132

Woodland Hills, California, 91364, United States

Location

Denver Arthritis Clinic /ID# 228172

Denver, Colorado, 80230, United States

Location

New England Research Associates, LLC /ID# 230127

Bridgeport, Connecticut, 06606-1827, United States

Location

Stamford Therapeutics Consorti /ID# 229214

Stamford, Connecticut, 06905, United States

Location

Delaware Arthritis /ID# 229413

Lewes, Delaware, 19958, United States

Location

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 228229

Boca Raton, Florida, 33486, United States

Location

Bay Area Arthritis and Osteo /ID# 228075

Brandon, Florida, 33511, United States

Location

Clinical Research of West Florida, Inc /ID# 228128

Clearwater, Florida, 33765, United States

Location

International Medical Research /ID# 228069

Daytona Beach, Florida, 32117, United States

Location

Omega Research Debary, LLC /ID# 228293

DeBary, Florida, 32713-2260, United States

Location

Neoclinical Research /ID# 228753

Hialeah, Florida, 33016-1897, United States

Location

University of Florida /ID# 228242

Jacksonville, Florida, 32209, United States

Location

Lakes Research, LLC /ID# 228665

Miami, Florida, 33014, United States

Location

University of Miami /ID# 228737

Miami, Florida, 33136, United States

Location

Suncoast Clinical Research /ID# 228237

New Port Richey, Florida, 34652, United States

Location

Omega Research Group /ID# 229966

Orlando, Florida, 32808, United States

Location

HMD Research LLC /ID# 228185

Orlando, Florida, 32819, United States

Location

Millennium Research /ID# 228183

Ormond Beach, Florida, 32174, United States

Location

Arthritis Center, Inc. /ID# 228209

Palm Harbor, Florida, 34684, United States

Location

BayCare Medical Group /ID# 228289

St. Petersburg, Florida, 33705, United States

Location

West Broward Rheumatology Associates /ID# 228603

Tamarac, Florida, 33321, United States

Location

Clinical Research of West Florida - Tampa /ID# 228186

Tampa, Florida, 33606-1246, United States

Location

Conquest Research /ID# 230560

Winter Park, Florida, 32789, United States

Location

Florida Medical Clinic /ID# 228236

Zephyrhills, Florida, 33542, United States

Location

Arthritis and Rheumatology /ID# 228743

Atlanta, Georgia, 30342, United States

Location

Jefrey D. Lieberman, MD, P.C. /ID# 230129

Decatur, Georgia, 30033, United States

Location

Arthritis Center of North GA /ID# 228769

Gainesville, Georgia, 30501, United States

Location

Atlanta Research Center for Rheumatology /ID# 230430

Marietta, Georgia, 20060, United States

Location

Great Lakes Clinical Trials /ID# 228699

Chicago, Illinois, 60640, United States

Location

Greater Chicago Specialty Physicians /ID# 228282

Schaumburg, Illinois, 60195-3106, United States

Location

Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 228174

Skokie, Illinois, 60076, United States

Location

Springfield Clinic /ID# 228124

Springfield, Illinois, 62702-3749, United States

Location

Beacon Medical Group Clinical Research /ID# 229153

Granger, Indiana, 46530, United States

Location

University of Iowa Hospitals and Clinics /ID# 229217

Iowa City, Iowa, 52242, United States

Location

Four Rivers Clinical Research /ID# 230109

Paducah, Kentucky, 42001, United States

Location

The Arthritis & Diabetes Clinic, Inc. /ID# 228221

Monroe, Louisiana, 71203, United States

Location

Klein and Associates MD /ID# 230145

Cumberland, Maryland, 21502, United States

Location

Klein and Associates MD - Hagerstown /ID# 230143

Hagerstown, Maryland, 21742, United States

Location

The Center for Rheumatology and Bone Research /ID# 228617

Wheaton, Maryland, 20902, United States

Location

AA Medical Research Center - Grand Blanc /ID# 228604

Grand Blanc, Michigan, 48439, United States

Location

Advanced Rheumatology, PC /ID# 228684

Lansing, Michigan, 48910, United States

Location

June DO, PC /ID# 229838

Lansing, Michigan, 48911, United States

Location

Arthritis Associates /ID# 230188

Hattiesburg, Mississippi, 39402, United States

Location

Rheumatology Consultants - Clinical Research /ID# 229208

Tupelo, Mississippi, 38801-4949, United States

Location

Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 228283

St Louis, Missouri, 63119-3845, United States

Location

West County Rheumatology /ID# 228102

St Louis, Missouri, 63131-1703, United States

Location

Logan Health Research /ID# 228273

Kalispell, Montana, 59901, United States

Location

Advanced Biomedical Research of America /ID# 228596

Las Vegas, Nevada, 89123, United States

Location

Innovative Health Research /ID# 229209

Las Vegas, Nevada, 89128, United States

Location

Arthritis and Osteoporosis Associates /ID# 229418

Freehold, New Jersey, 07728-8307, United States

Location

Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 228602

Voorhees Township, New Jersey, 08043, United States

Location

Albuquerque Center For Rheumatology /ID# 228709

Albuquerque, New Mexico, 87102, United States

Location

Albuquerque Clinical Trials, Inc /ID# 228925

Albuquerque, New Mexico, 87102, United States

Location

Arthritis and Osteo Assoc /ID# 228662

Las Cruces, New Mexico, 88011, United States

Location

Buffalo Rheumatology and Medicine - Orchard Park /ID# 228710

Orchard Park, New York, 14127, United States

Location

St. Lawrence Health System /ID# 229508

Potsdam, New York, 13676, United States

Location

DJL Clinical Research, PLLC /ID# 230133

Charlotte, North Carolina, 28211, United States

Location

Cape Fear Arthritis Care /ID# 228747

Leland, North Carolina, 28451, United States

Location

PMG Research of Salisbury /ID# 230627

Salisbury, North Carolina, 28144, United States

Location

Trinity Health Med Arts Clinic /ID# 228202

Minot, North Dakota, 58701, United States

Location

University of Cincinnati /ID# 229212

Cincinnati, Ohio, 45267-0585, United States

Location

Paramount Medical Research Con /ID# 228254

Middleburg Heights, Ohio, 44130, United States

Location

Arthritis Assoc of NW Ohio /ID# 228936

Toledo, Ohio, 43606, United States

Location

Arthritis and Rheumatology Center of Oklahoma /ID# 228975

Oklahoma City, Oklahoma, 73102, United States

Location

Rheumatology Associates of Oklahoma /ID# 228701

Oklahoma City, Oklahoma, 73116-7226, United States

Location

Advanced Rheumatology & Arthritis Wellness Center /ID# 228608

Cranberry Township, Pennsylvania, 16066, United States

Location

Altoona Ctr Clinical Res /ID# 230058

Duncansville, Pennsylvania, 16635, United States

Location

Arthritis Group /ID# 229777

Philadelphia, Pennsylvania, 19152, United States

Location

PA Regional Center for Arthritis and Osteoporosis Research /ID# 228742

Wyomissing, Pennsylvania, 19610, United States

Location

Columbia Arthritis Center /ID# 228705

Columbia, South Carolina, 29204, United States

Location

West Tennessee Research Institute /ID# 228257

Jackson, Tennessee, 38305, United States

Location

Arthritis and Rheumatology Research Institute, PLLC /ID# 228937

Allen, Texas, 75013-6147, United States

Location

Allen Arthritis /ID# 228712

Allen, Texas, 75013, United States

Location

Trinity Universal Research Associates - Carrollton /ID# 230104

Carrollton, Texas, 75007, United States

Location

Adriana Pop-Moody MD Clinic PA /ID# 230062

Corpus Christi, Texas, 78404, United States

Location

West Texas Clinical Research /ID# 228276

Lubbock, Texas, 79424, United States

Location

P&I Clinical Research /ID# 230183

Lufkin, Texas, 75904-3132, United States

Location

SW Rheumatology Res. LLC /ID# 228088

Mesquite, Texas, 75150, United States

Location

Trinity Universal Research Associates, Inc /ID# 228238

Plano, Texas, 75024-5283, United States

Location

Epic Medical Research /ID# 228097

Red Oak, Texas, 75154-3981, United States

Location

Sun Research Institute /ID# 228768

San Antonio, Texas, 78215, United States

Location

Advanced Rheumatology of Houston /ID# 228170

The Woodlands, Texas, 77382, United States

Location

DM Clinical Research - Tomball /ID# 228112

Tomball, Texas, 77375, United States

Location

Rheumatology Clinic of Houston /ID# 228178

Tomball, Texas, 77377, United States

Location

Arthritis & Osteoporosis Clinic /ID# 228736

Waco, Texas, 76710, United States

Location

Tidewater Physicians Medical Center /ID# 230130

Newport News, Virginia, 23606-4434, United States

Location

Arthritis Northwest, PLLC /ID# 228275

Spokane, Washington, 99204-2302, United States

Location

Emeritus Research Sydney /ID# 230070

Botany, New South Wales, 2019, Australia

Location

BJC Health /ID# 229015

Paramatta, New South Wales, 2150, Australia

Location

Rheumatology Research Unit Sunshine Coast /ID# 229017

Maroochydore, Queensland, 4558, Australia

Location

The Queen Elizabeth Hospital /ID# 230071

Woodville South, South Australia, 5011, Australia

Location

Emeritus Research /ID# 229018

Camberwell, Victoria, 3124, Australia

Location

Rheumatology Research Associates /ID# 227818

Edmonton, Alberta, T5M 0H4, Canada

Location

Manitoba Clinic /ID# 227822

Winnipeg, Manitoba, R3A 1M3, Canada

Location

Groupe de Recherche en Maladies Osseuses Inc /ID# 227821

Sainte-Foy, Quebec, G1V 3M7, Canada

Location

Centre de Recherche Musculo-Squelettique /ID# 227824

Trois-Rivières, Quebec, G8Z 1Y2, Canada

Location

Dr Naik-Medical Professional Corporation-Alliance Health /ID# 227823

Saskatoon, Saskatchewan, S7H 5M7, Canada

Location

Revmatologicky ustav v Praze /ID# 229188

Prague, 128 00, Czechia

Location

PV MEDICAL Services s.r.o. /ID# 228265

Prague, 130 00, Czechia

Location

Revmatologicka ambulance - MUDr. Zuzana Urbanova /ID# 227775

Prague, 140 00, Czechia

Location

Fakultni Nemocnice v Motole /ID# 231622

Prague, 150 06, Czechia

Location

MEDICAL PLUS, s.r.o. /ID# 228030

Uherské Hradiště, 686 01, Czechia

Location

RHEUMA s.r.o. /ID# 230850

Velké Bílovice, 691 02, Czechia

Location

Rheumazentrum Ruhrgebiet /ID# 227850

Herne, North Rhine-Westphalia, 44649, Germany

Location

Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 229526

Berlin, 10117, Germany

Location

MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 227785

Hamburg, 20095, Germany

Location

General Hospital of Athens Gennimatas /ID# 227806

Athens, Attica, 11527, Greece

Location

University General Hospital of Heraklion PA.G.N.I /ID# 227804

Heraklion, Crete, 71500, Greece

Location

424 General MILITARY Hospital /ID# 227805

Efkarpia (Thessalonikis), Thessaloniki, 56429, Greece

Location

General Hospital of Thessaloniki Hippokrateio /ID# 229614

Thessaloniki, 54642, Greece

Location

Debreceni Egyetem Klinikai Kozpont /ID# 228371

Debrecen, Hajdú-Bihar, 4032, Hungary

Location

Obudai Egeszsegugyi Centrum Kft. /ID# 228359

Budapest, Pest County, 1036, Hungary

Location

DRC Gyogyszervizsgalo Kozpont Kft /ID# 228365

Balatonfüred, 8230, Hungary

Location

Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 227671

Budapest, 1023, Hungary

Location

Revita Reumatologiai Rendelo /ID# 227668

Budapest, 1027, Hungary

Location

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 227670

Székesfehérvár, 8000, Hungary

Location

Vital Medical Center Orvosi es Fogaszati Kozpont (Vital Medicina Kft.) /ID# 227669

Veszprém, 8200, Hungary

Location

Obudai Egeszsegugyi Centrum Kft. Zalaegerszeg /ID# 228374

Zalaegerszeg, 8900, Hungary

Location

Meir Medical Center /ID# 226800

Kfar Saba, Central District, 4428164, Israel

Location

Rambam Health Care Campus /ID# 226798

Haifa, H_efa, 3109601, Israel

Location

Bnai Zion Medical Center /ID# 226801

Haifa, H_efa, 3339419, Israel

Location

The Lady Davis Carmel Medical Center /ID# 226802

Haifa, H_efa, 34362, Israel

Location

The Chaim Sheba Medical Center /ID# 226797

Ramat Gan, Tel Aviv, 5265601, Israel

Location

Tel Aviv Sourasky Medical Center /ID# 228341

Tel Aviv, Tel Aviv, 6423906, Israel

Location

Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 228917

Rome, Lazio, 00128, Italy

Location

Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 228581

Ancona, 60126, Italy

Location

Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228583

Palermo, 90127, Italy

Location

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 229899

Nagoya, Aichi-ken, 455-8530, Japan

Location

Daido Clinic /ID# 229280

Nagoya, Aichi-ken, 457-8511, Japan

Location

Sugimoto rheumatology and internal medicine clinic /ID# 229495

Fukui-shi, Fukui, 910-0068, Japan

Location

Hamanomachi Hospital /ID# 228644

Fukuoka, Fukuoka, 810-8539, Japan

Location

National Hospital Organization Kyushu Medical Center /ID# 228642

Fukuoka, Fukuoka, 810-8563, Japan

Location

Shono Rheumatism Clinic /ID# 229054

Fukuoka, Fukuoka, 814-0002, Japan

Location

Katayama Orthopedic Rheumatology Clinic /ID# 229277

Asahikawa-shi, Hokkaido, 078-8243, Japan

Location

Sagawa Akira Rheumatology Clin /ID# 228787

Sapporo, Hokkaido, 060-0001, Japan

Location

Matsubara Mayflower Hospital /ID# 228948

Kato-shi, Hyōgo, 673-1462, Japan

Location

Sanuki Municipal Hospital /ID# 229276

Sanuki-shi, Kagawa-ken, 769-2393, Japan

Location

Bay Side Misato Medical Center /ID# 228947

Kochi, Kochi, 781-0112, Japan

Location

Kumamoto Orthopaedic Hospital /ID# 228641

Kumamoto, Kumamoto, 8620975, Japan

Location

Medical Corporation Keiai Kai Clinic /ID# 228547

Miyazaki, Miyazaki, 880-0053, Japan

Location

Sasebo Chuo Hospital /ID# 229168

Sasebo-shi, Nagasaki, 857-1195, Japan

Location

Nagaoka Red Cross Hospital /ID# 229962

Nagaoka-shi, Niigata, 940-2085, Japan

Location

National Hospital Organization Osaka Minami Medical Center /ID# 229174

Kawachinagano Shi, Osaka, 586-8521, Japan

Location

Osaka City General Hospital /ID# 228786

Osaka, Osaka, 534-0021, Japan

Location

Japanese Red Cross Osaka Hospital /ID# 229816

Osaka, Osaka, 543-8555, Japan

Location

Azuma Rheumatology Clinic /ID# 230078

Sayama-shi, Saitama, 350-1305, Japan

Location

St.Luke's International Hospital /ID# 229492

Chuo-ku, Tokyo, 104-8560, Japan

Location

National Hospital Organization Tokyo Medical Center /ID# 228720

Meguro-ku, Tokyo, 152-8902, Japan

Location

Medical Corporation Uchida Clinic /ID# 229494

Sumida-ku, Tokyo, 130-0013, Japan

Location

Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 228354

Shimonoseki-shi, Yamaguchi, 752-0976, Japan

Location

Academisch Medisch Centrum /ID# 227234

Amsterdam, 1105 AZ, Netherlands

Location

Maastricht Universitair Medisch Centrum /ID# 227235

Maastricht, 6229 HX, Netherlands

Location

Aotearoa Clinical Trials /ID# 229012

Papatoetoe, Auckland, 2025, New Zealand

Location

Timaru Medical Specialists Ltd /ID# 229013

Timaru, Canterbury, 7910, New Zealand

Location

Wellington Regional Hospital /ID# 233517

Newtown, Wellington Region, 6021, New Zealand

Location

Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 227939

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

Location

Centrum Medyczne Reuma Park /ID# 227170

Warsaw, Masovian Voivodeship, 02-691, Poland

Location

SANUS Szpital Specjalistyczny /ID# 227171

Stalowa Wola, Podkarpackie Voivodeship, 37-450, Poland

Location

ClinicMed Daniluk, Nowak Sp.k. /ID# 227919

Bialystok, Podlaskie Voivodeship, 15-879, Poland

Location

Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 228047

Gdansk, Pomeranian Voivodeship, 80-546, Poland

Location

MICS Centrum Medyczne Warszawa /ID# 231133

Warsaw, 00-874, Poland

Location

AMICARE Sp. z o.o. sp.k. /ID# 231327

Lodz, Łódź Voivodeship, 90-644, Poland

Location

GCM Medical Group PSC /ID# 228981

San Juan, 00917-3104, Puerto Rico

Location

Mindful Medical Research /ID# 228982

San Juan, 00918-3756, Puerto Rico

Location

LLC Family Outpatient Clinic No /ID# 227926

Korolev, Moscow, 141060, Russia

Location

Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 228755

Moscow, Moscow Oblast, 129110, Russia

Location

Family Clinic /ID# 227929

Yekaterinburg, Sverdlovsk Oblast, 620109, Russia

Location

Kazan State Medical University /ID# 227927

Kazan', Tatarstan, Respublika, 420012, Russia

Location

Central Clinical Hospital of Russian Academy of Science /ID# 229438

Moscow, 117593, Russia

Location

Euromedservice /ID# 227933

Pushkin, 196603, Russia

Location

Clinical Rheumatologic Hospital No 25 /ID# 227922

Saint Petersburg, 190068, Russia

Location

MEDMAN s.r.o. /ID# 227826

Martin, 036 01, Slovakia

Location

Reum.hapi s.r.o. /ID# 227825

Nové Mesto nad Váhom, 915 01, Slovakia

Location

Thermium s.r.o. /ID# 227816

Piešťany, 921 01, Slovakia

Location

REUMAMED POPRAD s.r.o. /ID# 229628

Poprad, 058 01, Slovakia

Location

Reumex, s.r.o. /ID# 227827

Rimavská Sobota, 979 01, Slovakia

Location

SoonChunHyang University CheonAn Hospital /ID# 228146

Cheonan-si, Chungcheongnam-do, 31151, South Korea

Location

Yonsei University Health System Severance Hospital /ID# 227659

Seoul, Seoul Teugbyeolsi, 03722, South Korea

Location

Hanyang University Seoul Hospital /ID# 227658

Seoul, Seoul Teugbyeolsi, 04763, South Korea

Location

Kyungpook National University Hospital /ID# 227657

Daegu, 41944, South Korea

Location

Inha University Hospital /ID# 227656

Incheon, 22332, South Korea

Location

Asan Medical Center /ID# 227655

Seoul, 05505, South Korea

Location

Hospital Clínico Universitario de Santiago-CHUS /ID# 227420

Santiago de Compostela, A Coruna, 15706, Spain

Location

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 227666

Sabadell, Barcelona, 08208, Spain

Location

Hospital Universitario Basurto /ID# 227667

Bilbao, Vizcaya, 48013, Spain

Location

Hospital Universitario A Coruna - CHUAC /ID# 227419

A Coruña, 15006, Spain

Location

Hospital Universitario Fundacion Jimenez Diaz /ID# 234115

Madrid, 28040, Spain

Location

Hospital Universitario 12 de Octubre /ID# 227743

Madrid, 28041, Spain

Location

Hospital Regional Universitario de Malaga /ID# 227418

Málaga, 29011, Spain

Location

Hospital Universitario Virgen de Valme /ID# 227417

Seville, 41014, Spain

Location

Hospital Universitario y Politecnico La Fe /ID# 227408

Valencia, 46026, Spain

Location

Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 227220

Chiayi City, 62247, Taiwan

Location

Far Eastern Memorial Hospital /ID# 227373

New Taipei City, 22060, Taiwan

Location

National Taiwan University Hospital /ID# 230001

Taipei, 100, Taiwan

Location

Taipei Veterans General Hosp /ID# 227376

Taipei, 11217, Taiwan

Location

Hacettepe Universitesi Tip Fak /ID# 227796

Sihhiye, Ankara, 06100, Turkey (Türkiye)

Location

Ankara Univ Medical Faculty /ID# 227797

Ankara, 06590, Turkey (Türkiye)

Location

Kocaeli University Med Faculty /ID# 228244

Kocaeli, 41380, Turkey (Türkiye)

Location

MNI City Multidisciplinary Hospital #18 Kharkiv City Council /ID# 228961

Kharkiv, 61029, Ukraine

Location

Khmelnytskyi Regional Hospital /ID# 230680

Khmelnytskyi, 29000, Ukraine

Location

Medical Center of Medical Clinic Blagomed LLC /ID# 228956

Kyiv, 01023, Ukraine

Location

Medical Center "OK! Clinic+" LLC, "International Institute of Clinical Research" /ID# 228958

Kyiv, 02091, Ukraine

Location

Medical Center CONSILIUM MEDICAL /ID# 228959

Kyiv, 04050, Ukraine

Location

PI "Poltava Regional Clinical Hospital n.a. M.V.Sklifosovsky of PCC" /ID# 228962

Poltava, 36011, Ukraine

Location

CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 228954

Vinnytsia, 21018, Ukraine

Location

Сlinic Scientific Research Inst of Invalid Rehab ESMС M I Pyrogov VNMU /ID# 228955

Vinnytsia, 21029, Ukraine

Location

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Global Medical Services
Organization
AbbVie

Study Officials

  • ABBVIE INC.

    AbbVie

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 13, 2021

First Posted

May 17, 2021

Study Start

June 23, 2021

Primary Completion

August 25, 2022

Study Completion

August 4, 2023

Last Updated

October 8, 2024

Results First Posted

October 8, 2024

Record last verified: 2024-09

Data Sharing

IPD Sharing
Will share

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/
Access Criteria
Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous independent scientific research, and will be provided following review and approval of a research proposal and statistical analysis plan and execution of a data sharing statement. Data requests can be submitted at any time after approval in the US and/or EU and a primary manuscript is accepted for publication. For more information on the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
More information

Locations