NCT04887727|Completed
Loading search results
Sponsor study identifier
interventional
22
1 country
1
Study Start
February 25, 2019
Actual (reported)Primary Completion
August 31, 2019
Actual (reported)Study Completion
August 31, 2019
Actual (reported)Previous studies have used a combination of oral L-\[1-13C\]leucine and intravenous labeled L-\[5,5,5-2H3\]leucine to assess the acute postprandial changes in whole-body protein turnover (12, 19). Intravenous and dietary-labeled amino acid tracers have also been used in tandem to assess rates of myofibrillar protein synthesis in response to bolus protein ingestion and resistance exercise (46). By validating whole-body net balance to myofibrillar protein synthesis, our proposed multi-tracer approach will develop minimally invasive models to study protein turnover in a variety of populations in which traditional infusions and/or repeated blood samples are not possible (i.e. pediatric, free-living populations).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 31, 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 25, 2019
Actual (reported)August 31, 2019
Actual (reported)August 31, 2019
Actual (reported)May 5, 2021
Actual (reported)May 14, 2021
Actual (reported)Myofibrillar protein synthesis rates
Myofibrillar protein synthesis rates assessed by oral and intravenous tracers during Fast, Fed, and Ex-Fed
5 hours
Whole-body protein turnover
5 hours
Amino acid oxidation and net protein balance
5 hours
Muscle anabolic signalling
2 and 5 hours
Amino acid transporter expression
2 and 5 hours
Subjects receive 0.25g/kg crystalline amino acids modelled after egg protein, enriched with L-\[1-13C\]leucine and L-ring-\[2H5\]phenylalanine with a primed-constant infusion of L-\[555-2H3\]leucine to assess myofibrillar protein synthesis rates
Subjects receive 0.25g/kg crystalline amino acids modelled after egg protein, enriched with L-\[1-13C\]leucine with a primed-constant infusion of L-\[555-2H3\]leucine to whole-body protein turnover, amino acid oxidation, and net protein balance
Amino acid dose = 0.25g/kg bodyweight
Amino acid dose = 0.25g/kg bodyweight
Goldring Centre for High Performance Sport at the University of Toronto
Toronto, Ontario, M5S2C9, Canada
Mazzulla M, Hodson N, West DWD, Kumbhare DA, Moore DR. A non-invasive 13CO2 breath test detects differences in anabolic sensitivity with feeding and heavy resistance exercise in healthy young males: a randomized control trial. Appl Physiol Nutr Metab. 2022 Aug 1;47(8):860-870. doi: 10.1139/apnm-2021-0808. Epub 2022 May 24.
Daniel R Moore, PhD
University of Toronto
22 participants (actual enrollment reported by the registry).
First Submitted
May 5, 2021
First Posted
May 14, 2021
Study Start
February 25, 2019
Actual (reported)Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Brown Rice
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
August 31, 2019
Actual (reported)Study Completion
August 31, 2019
Actual (reported)Last Updated
May 14, 2021
Record last verified: 2021-05
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: