NCT02009917|CompletedDMC
Non- Essential Amino Acid Requirements and Metabolism in Humans
Application of Indicator Amino Acid Oxidation Technique to Determine Non-essential Amino Acids/Nitrogen Requirements in Adult Humans
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Application of Indicator Amino Acid Oxidation Technique to Determine Non-essential Amino Acids/Nitrogen Requirements in Adult Humans
Sponsor study identifier
observational
6
1 country
1
Study Start
October 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2015
Actual (reported)Study Completion
April 2015
Actual (reported)Protein is a major structural component of all cells in the body. The nutritional importance of protein is because of their amino acids. 9 are called essential and 11 are called non-essential, based on whether we need to get them from diet. This classification is based on studies done using older techniques. Recent studies suggest that these so called non-essential amino acids play important roles in our body's health. For the first time, this proposal defines an experimental design to examine non- essential amino acid/nitrogen requirements and metabolism in humans using the Indicator Amino Acid Oxidation (IAAO) technique. The objective of the current study is to examine the application of IAAO technique to determine the non-essential amino acid/nitrogen requirement in adult humans.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 2013
Date type not reportedThis date has not been verified as actual or estimated.
December 9, 2013
Actual (reported)December 12, 2013
Actual (reported)January 2015
Actual (reported)April 2015
Actual (reported)13 Carbon dioxide production
Urine and breath samples will be collected to measure the rate of oxidation of expired breath and flux by enrichment of urine.
8 hours (1study day)
Physiologically Healthy Adult males, 20-40 years of age
Child and Family Research Institute
Vancouver, British Columbia, V5Z4H4, Canada
Cooper L, Ball RO, Pencharz PB, Sakai R, Elango R. Dispensable Amino Acids, except Glutamine and Proline, Are Ideal Nitrogen Sources for Protein Synthesis in the Presence of Adequate Indispensable Amino Acids in Adult Men. J Nutr. 2020 Sep 1;150(9):2398-2404. doi: 10.1093/jn/nxaa180.
Breath and urine samples
Rajavel Elango, Ph.D
University of British Columbia
6 participants (actual enrollment reported by the registry).
First Submitted
December 9, 2013
First Posted
December 12, 2013
Study Start
October 2013
Date type not reportedThis date has not been verified as actual or estimated.
Comparing The Effect of Proprioceptive Neuromuscular Facilitation (PNF) When Coupled With Dry Needling (DN), Acupuncture (AN) or Sham Needling (SN) on Knee Range of Motion (ROM), Jump Height and Unipedal Balance
Contact the study team to confirm eligibility.
Primary Completion
January 2015
Actual (reported)Study Completion
April 2015
Actual (reported)Last Updated
July 18, 2017
Record last verified: 2017-07
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Source: ClinicalTrials.gov.
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