Mirror Therapy and Cross-Education of Muscle Strength

NCT04887376 | Completed

• 1 other identifier: IstPMRTRH-MT
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted to determine whether mirror therapy has an additive effect on cross-education of the strength of neuromuscular electrical stimulation (NMES) in patients with hemiplegia. As an outcome measure, the ankle dorsiflexion strength of hemiplegic patients was measured.

Conditions

Cerebrovascular Stroke; Muscle Weakness

Keywords

Cross-education; Neuromuscular electrical stimulation; Mirror Therapy

Outcome Measures

Primary Outcomes (1)

• Change of ankle dorsiflexor isometric muscle strength

  Force transducer used for measuring maximum voluntary ankle dorsiflexion force. The force unit is kilogram.force

  Change from Baseline muscle strength at 6 days

Secondary Outcomes (4)

• Change of Lower Extremity Brunnstrom score

  Change from Baseline Brunnstrom score at 6 days

• Change of Modified Ashworth Scale score

  Change from Baseline Modified Ashworth Scale score at 6 days

• Change of Functional Ambulation Scale score

  Change from Baseline Functional Ambulation Scale score at 6 days

• Change of Timed Up and Go Test score

  Change from Baseline Timed Up and Go Test score at 6 days

Study Arms (2)

Mirror Therapy

ACTIVE COMPARATOR

Participants were asked to sit with their knee joints in full extension and both ankle joints in a neutral position. Five sessions of neuromuscular electrical stimulation (NMES) were applied to the non-affected side ankle dorsiflexors. In addition to this application, mirror therapy was applied simultaneously with NMES.

Device: Mirror frame

Control

PLACEBO COMPARATOR

Participants were asked to sit with their knee joints in full extension and both ankle joints in a neutral position. Five sessions of neuromuscular electrical stimulation (NMES) were applied to the non-affected side ankle dorsiflexors.

Device: Control

Interventions

Mirror frame DEVICE

Combined Mirror and NMES therapy

Mirror Therapy

Control DEVICE

Only NMES therapy

Control

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Cases with stroke duration ≥ 1 month
• Ability to walk at least 10m (functional ambulation scale ≥3)
• Age range 18-75 years
• Hemorrhagic or ischemic stroke
• Brunnstrom stage ≥4 for lower limb
• Unilateral stroke
• Cooperating with the examination and tests

You may not qualify if:

• Mini Mental State Assessment score \<21
• Severe spasticity (MAS = 4) in ankle dorsiflexors
• Have a contracture on ankle joint
• The presence of skin lesions in the application area
• Painful pathologies in the lower extremities
• Having visual field defects
• Active inflammatory, rheumatological or infectious disease
• Parent rhythm / conduction block problem in the heart
• Uncontrollable hypertension (Maxima\> 140, Minima\> 90)
• Presence of lower extremity fracture
• Peripheral nerve lesions such as polyneuropathy, radiculopathy
• Finding or suspected active deep vein thrombosis
• History of deep vein thrombosis and pulmonary embolism

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training & Research Hospital

Istanbul, 34173, Turkey (Türkiye)

Location

Related Publications (6)

• Howatson G, Zult T, Farthing JP, Zijdewind I, Hortobagyi T. Mirror training to augment cross-education during resistance training: a hypothesis. Front Hum Neurosci. 2013 Jul 24;7:396. doi: 10.3389/fnhum.2013.00396. eCollection 2013.

  PMID: 23898251 BACKGROUND

• Zult T, Goodall S, Thomas K, Solnik S, Hortobagyi T, Howatson G. Mirror Training Augments the Cross-education of Strength and Affects Inhibitory Paths. Med Sci Sports Exerc. 2016 Jun;48(6):1001-13. doi: 10.1249/MSS.0000000000000871.

  PMID: 26765630 BACKGROUND

• Sariyildiz M, Karacan I, Rezvani A, Ergin O, Cidem M. Cross-education of muscle strength: cross-training effects are not confined to untrained contralateral homologous muscle. Scand J Med Sci Sports. 2011 Dec;21(6):e359-64. doi: 10.1111/j.1600-0838.2011.01311.x. Epub 2011 Apr 18.

  PMID: 21496110 BACKGROUND

• Lee D, Lee G. Effect of afferent electrical stimulation with mirror therapy on motor function, balance, and gait in chronic stroke survivors: a randomized controlled trial. Eur J Phys Rehabil Med. 2019 Aug;55(4):442-449. doi: 10.23736/S1973-9087.19.05334-6. Epub 2019 Mar 22.

  PMID: 30916531 BACKGROUND

• Kim H, Lee G, Song C. Effect of functional electrical stimulation with mirror therapy on upper extremity motor function in poststroke patients. J Stroke Cerebrovasc Dis. 2014 Apr;23(4):655-61. doi: 10.1016/j.jstrokecerebrovasdis.2013.06.017. Epub 2013 Jul 16.

  PMID: 23867040 BACKGROUND

• Ji SG, Cha HG, Kim MK, Lee CR. The effect of mirror therapy integrating functional electrical stimulation on the gait of stroke patients. J Phys Ther Sci. 2014 Apr;26(4):497-9. doi: 10.1589/jpts.26.497. Epub 2014 Apr 23.

  PMID: 24764619 BACKGROUND

MeSH Terms

Conditions

Stroke; Muscle Weakness

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Ilhan Karacan, Assoc Prof

  Istanbul Physical Medicine Rehabilitation Training & Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Randomized controlled trial

Study Record Dates

• First Submitted: May 7, 2021
• First Posted: May 14, 2021
• Study Start: February 1, 2020
• Primary Completion: January 31, 2021
• Study Completion: January 31, 2021
• Last Updated: May 14, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)