Studies of the Angle Kappa and the Angle Alpha

NCT04886219 | Completed

• 2 other identifiers: APHP2102892020-A03370-39
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive...) or in clinical practice. The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination. The aim of the study is to analyze the correlation between the angle alpha and the angle kappa in a healthy individual without ophthalmologic disorder.

Conditions

No Eye Disorder

Keywords

Angle Kappa; Angle Alpha; Pupillary axis; Visual axis; Optical axis

Outcome Measures

Primary Outcomes (2)

• Value of the angle Kappa

  Semi-automatic digital method of measurement by eye photography

  Day 0

• Value of the angle Alpha

  Semi-automatic digital method of measurement by eye photography

  Day 0

Secondary Outcomes (3)

• Variation of the Kappa angle depending on the pupillary diameter

  Day 0

• Correlation between the value of the angle Alpha and the Optic disc / fovea distance

  Day 0

• Correlation between the angle Kappa and the axial length

  Day 0

Study Arms (1)

Healthy individual

Healthy individual

Other: Eye examination

Interventions

Eye examination OTHER

* Multimodal fundus imaging (color fundus photography, optical coherence tomography (OCT)) * orthoptic assessment (Visual acuity, Refraction, Cover test, Stereopsis evaluation * ocular biometry * corneal topography * monocular photographs in photopic and scotopic condition

Healthy individual

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy individuals without visual disorders

You may qualify if:

• \- Informed major subject not opposing to their participation in the study

You may not qualify if:

• \- Subject with strabismus or organic ophthalmologic pathology

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• URC-CIC Paris Descartes Necker Cochin: collaborator

Study Sites (1)

Hôpital Necker-Enfants Malades

Paris, 75015, France

Location

Related Publications (2)

• Rateaux M, Vienne-Jumeau A, Bremond-Gignac D, Robert MP. Fluctuations in angle lambda with the pupil diameter and correlations with biometric values in a healthy population. Ophthalmic Physiol Opt. 2025 Nov;45(7):1837-1844. doi: 10.1111/opo.70006. Epub 2025 Aug 14.

  PMID: 40810703 BACKGROUND

• Rateaux M, Bremond-Gignac D, Robert MP. From monocular photograph to angle lambda: A new clinical approach for quantitative assessment. J Binocul Vis Ocul Motil. 2022 Jul-Sep;72(3):169-175. Epub 2022 Jun 22.

  PMID: 35731900 BACKGROUND

Study Officials

• Maxence Rateaux

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

• Dominique Brémond-Gignac, MD, PhD

  Assistance Publique - Hôpitaux de Paris

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 10, 2021
• First Posted: May 14, 2021
• Study Start: May 19, 2021
• Primary Completion: October 4, 2021
• Study Completion: October 4, 2021
• Last Updated: September 19, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)