Efficacy of Injection Platelet-rich Fibrin(I-PRF) in Accelerate Alignment and Leveling

NCT04885842 | Completed

• 1 other identifier: TishreenU
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

the aim of this study is to evaluate the effectiveness of injection I-PRF to accelerate alignment and leveling of the upper anterior teeth and reduce the time required for treatment.

Conditions

Orthodontic Pathological Resorption of External Root

Outcome Measures

Primary Outcomes (1)

• alignment and leveling Improvement Percentage(ALIP):

  Determining the percentage of improvement in alignment and leveling by calculating the value of the change in the Little index in one of the studied time periods (T1) or (T2) or (T3) which is calculated by subtracting the value of the Little index at the studied period of time from the value of the Little index at (T0) When the primary wire is inserted, the value of the little index at (T0) is multiplied by 100 Through the following

  6 Month

Secondary Outcomes (1)

• Overall Alignment and Leveling Time

  6 Month

Study Arms (2)

Study Group

EXPERIMENTAL

injection I-PRF with brackets

Other: injection I-PRF

Control Group

NO INTERVENTION

applying brackets only

Interventions

injection I-PRF OTHER

injection I-PRF with brackets

Also known as: control Group

Study Group

Eligibility Criteria

• Age: 16 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• The Clinical Diagnosis the age of patients ranges between 16-24 years, medium crowding between 3-6 mm in the area of the upper anterior teeth according to Little irregularity index 20,class1 according angel classification,

You may not qualify if:

• the presence of any systemic disease that affects the orthodontic movement Diabetes , a patient undergoing previous orthodontic treatment, a patient who takes medicines Cortisone,NSAIDs the affect dental movement . and the presence of bleeding disorders Disturbance in the number of platelets.

Sponsors & Collaborators

• Tishreen University: lead

Study Sites (1)

Tishreen University

Latakia, Syria

Location

Related Publications (2)

• The gliding path of the mandible along the skull. Ferdinand Graf Spee (1855-1937), prosector at the Anatomy Institute of Kiel. J Am Dent Assoc. 1980 May;100(5):670-5. No abstract available.

  PMID: 6988491 RESULT

• Baldridge DW. Leveling the curve of Spee: its effect on mandibular arch length. JPO J Pract Orthod. 1969 Jan;3(1):26-41. No abstract available.

  PMID: 5250875 RESULT

Related Links

• Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent 2009;1:21-30

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A randomized controlled clinical study ,two parallel groups design. The research sample consisted of 18 patients (11 famales,7 males)Patients were randomly assigned to 2 groups using the sample randomization principle. Each group included 8 patient (9 control group applying brackets only)(9 group injection I-PRF with brackets).

Study Record Dates

• First Submitted: May 9, 2021
• First Posted: May 13, 2021
• Study Start: September 14, 2019
• Primary Completion: February 18, 2021
• Study Completion: March 3, 2021
• Last Updated: May 17, 2021

Record last verified: 2021-03

Locations

SY (1)