Collateral Circulation in Acute Ischemic Stroke With Large Vessel Occlusion
COLISEUM
Collateral Circulation ("Collaterome") in Acute Ischemic Stroke With Large Vessel Occlusion: A Study of Clinical, Radiological, Plasma and Genetic Factors.
1 other identifier
observational
700
0 countries
N/A
Brief Summary
Prospective multicenter study of consecutive patients with acute ischemic stroke and large intracranial vessel occlusion in which a thorough and systematic evaluation of all variables that may be related to the degree of collateral circulation is performed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2021
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 5, 2019
CompletedFirst Posted
Study publicly available on registry
May 12, 2021
CompletedStudy Start
First participant enrolled
June 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedMay 12, 2021
May 1, 2021
1.3 years
December 5, 2019
May 11, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Collateral Circulation grade
Trough the acute phase of stroke, an average of 24 hours
Eligibility Criteria
Patients with acute ischemic stroke and a large-vessel intracranial occlusion.
You may qualify if:
- Patients with acute ischemic stroke.
- Large vessel occlusion of an intracranial internal artery: M1, M2 or TICA. (terminal intracranial carotid artery), as demonstrated by CTA.
- CTA performed within the first 24 hours after stroke onset. Patients with wake-up stroke are included.
- A previous modified Rankin Scale score of 0 to 3.
- The patient or a legal representative signs a written consent to participate.
You may not qualify if:
- More than 24 hours from last been known to be well.
- Occlusion of other arterial segments (vertebrobasilar circulation, A1, P1, M3, M4).
- Age below 18 years.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Paulead
- Instituto de Salud Carlos IIIcollaborator
- Complejo Hospitalario Universitario de Albacetecollaborator
- Hospital de Crucescollaborator
- Hospital Clínico Universitario de Valladolidcollaborator
- Hospitales Universitarios Virgen del Rocíocollaborator
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesacollaborator
- Hospital Universitario La Pazcollaborator
- Hospital del Marcollaborator
- Hospital Arnau de Vilanovacollaborator
- Complexo Hospitalario Universitario de A Coruñacollaborator
- Red de Enfermedades Vasculares Cerebrales INVICTUS PLUS (Rd1600190024)collaborator
Biospecimen
Blood sampling will be obtained by venipuncture in EDTA tubes at admission and processed at each center. Samples will be sent to the promoter site for genetic and plasma markers analysis.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 5, 2019
First Posted
May 12, 2021
Study Start
June 1, 2021
Primary Completion
September 30, 2022
Study Completion
December 31, 2022
Last Updated
May 12, 2021
Record last verified: 2021-05