Neuropsychological Indicators of SCD Progression

NCT04880252 | Completed

• 1 other identifier: PI2019_843_0039
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable. The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Conditions

Biomarkers; Cognitive Assessment; Cognitive Decline; Neurocognitive Disorders; Neurodegenerative Diseases; Subjective Cognitive Decline

Keywords

Biomarkers; Cognitive assessment; Cognitive decline; Neurocognitive disorders; Neurodegenerative diseases; Neuropsychological assessment; Risk of progression; Subjective cognitive decline

Outcome Measures

Primary Outcomes (1)

• Variation of neuropsychological indicators (global congnitive score) between NCD et SCD patients

  subjective cognitive decline (SCD) neurocognitive disorders (NCD) neuropsychological indicators could discriminate between people in whom SCD progressed to a mild or major NCD and people in whom SCD remained stable. A global cognitive score was created using all 5 tests : Alice Heim 4-I tests inductive reasoning ; Short-term verbal memory was assessed with a 20-word free-recall test; Two measures of verbal fluency were used: phonemic and semantic; Vocabulary was assessed using the Mill Hill Vocabulary test.

  one year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart.

You may qualify if:

• patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France).
• patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005
• patients who met the criteria for SCD.

You may not qualify if:

• patients who didn't meet the criteria for SCD

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80480, France

Location

Related Publications (1)

• Perron A, Roussel M, Wannepain-Despretz S, Barbay M, Devendeville A, Godefroy O, Andriuta D. In Individuals With Subjective Cognitive Decline, Age, Memory and Speed Scores at Baseline Predict Progression to Cognitive Impairment. Alzheimer Dis Assoc Disord. 2022 Oct-Dec 01;36(4):359-361. doi: 10.1097/WAD.0000000000000520. Epub 2022 Jul 19.

  PMID: 35867966 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction; Neurocognitive Disorders; Neurodegenerative Diseases

Condition Hierarchy (Ancestors)

Cognition Disorders; Mental Disorders; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 4, 2021
• First Posted: May 10, 2021
• Study Start: May 1, 2019
• Primary Completion: May 1, 2020
• Study Completion: May 1, 2020
• Last Updated: May 10, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)