Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19
MicroCovAging
1 other identifier
observational
229
1 country
1
Brief Summary
During the ongoing COVID-19 pandemic, age was clearly the major factor of mortality. Increasing age was strongly associated with this risk, with the upper 80 years age group having more than 12-fold increased risk compared with those aged 50-59 years. Male gender was also associated with a doubling of risk. The elderly subject is particularly exposed to global denutrition with risk of micronutrients deficiencies such as vitamins and trace elements. Those deficits expose to lower immunity. In addition, viral infection as COVID-19 can also worsen these deficits. In general, low levels or intakes of micronutrients such as Zn, Se and vitamin A have been associated with adverse clinical outcomes during viral infections. This notion has been confirmed in a recent review proposing that besides vitamins A and D also B vitamins, vitamin C, omega-3 polyunsaturated fatty acids, as well as selenium, zinc and iron should be considered in the assessment of micronutrients in COVID-19 patients. In this context, the MicroCovAging study will evaluate copper, zinc and selenium, vitamin A, D and E status in elderly subjects affected by COVID- 19 and to correlate this status with prognosis of this disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedFirst Submitted
Initial submission to the registry
March 4, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2021
CompletedFirst Posted
Study publicly available on registry
May 7, 2021
CompletedMay 7, 2021
March 1, 2021
9 months
March 4, 2021
May 5, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Selenium, Zinc and Copper, Vitamin A, D and E plasma concentrations of 229 over 50 year's patients hospitalized suffering from COVID-19.
Up to 3 months
Study Arms (1)
Over 50 year's COVID-19 patients hospitalized at HCL from 1st March to 29th May 2020.
Interventions
Micronutrient assays on heparinized plasma.
Eligibility Criteria
This is an observational study based on a monocentric historical cohort of ≥ 50 years patients hospitalized at HCL from 1st March 2020 to 30th May 2020and suffering from COVID-19.
You may qualify if:
- Hospitalized adult patient ≥ 50 years at the time of admission,
- Suffering from confirmed COVID-19 (positive quantitative PCR for SARS-CoV-2 and/or chest scanner suggestive of COVID-19),
- Informed and non-opposed to the research. Patient will be informed of the study by his medical doctor during hospitalization or by post thanks to a generic information sheet dedicated to COVID-19 researches.
You may not qualify if:
- Adult patient \< 50 years at the time of admission
- Negative quantitative PCR for SARS-Cov-2
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chls Cbap
Pierre-Bénite, France
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 4, 2021
First Posted
May 7, 2021
Study Start
March 1, 2020
Primary Completion
December 1, 2020
Study Completion
May 1, 2021
Last Updated
May 7, 2021
Record last verified: 2021-03