NCT04871126

Brief Summary

To investigate the predictive value of inflammatory indexes and CHA2DS2-VASc score for anterior myocardial infarction (ANT-MI) with left ventricular thrombus(LVT) (LVT).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
371

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2014

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2014

Completed
7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2021

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 25, 2021

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 4, 2021

Completed
Last Updated

May 4, 2021

Status Verified

April 1, 2021

Enrollment Period

7 years

First QC Date

April 25, 2021

Last Update Submit

April 28, 2021

Conditions

Keywords

left ventricular thrombus;anterior myocardial infarctionRisk factors

Outcome Measures

Primary Outcomes (1)

  • the predictive of the inflammatory indexes and CHA2DS2-VASc score in LVT

    the logistic regression model was established between the indexes and LVT

    Day 1

Study Arms (2)

LVT group

left ventricular thrombus in acute anterior myocardial infarction patients with left ventricular dysfunction

Other: inflammatory indexes and CHA2DS2-VASc score

non-LVTgroup

acute anterior myocardial infarction patients with left ventricular dysfunction while without LVT

Other: inflammatory indexes and CHA2DS2-VASc score

Interventions

inflammatory indexes and CHA2DS2-VASc score

LVT groupnon-LVTgroup

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study included a total of 371 patients with anterior myocardial infarction (ANT-MI) treated with emergency prior percutaneous coronary intervention (pPCI) in our hospital betweenfrom January 2014 andto January 2021. Patients were eligible for enrollmentenrolment if they had a reduced left ventricularLV ejection fraction (LVEF) ( ≤40%). and if detailed data on demographic and clinical characteristics were documented. Exclusion criteria were end-stage organic disease, thrombotic hematological disorders, previous anticoagulant use, and poor echogenicity (Figure 1). Based on the study criteria, 123 patients were excluded from the study; thus, 248 patients were included in the analysis.

You may qualify if:

  • acute anterior myocardial infarction with left ventricular dysfunction

You may not qualify if:

  • end-stage organic disease, thrombotic hematological disorders, previous anticoagulant use, and poor echogenicity

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood

MeSH Terms

Conditions

Anterior Wall Myocardial InfarctionVentricular Dysfunction, Left

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisVentricular Dysfunction

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 25, 2021

First Posted

May 4, 2021

Study Start

January 1, 2014

Primary Completion

January 1, 2021

Study Completion

January 1, 2021

Last Updated

May 4, 2021

Record last verified: 2021-04