Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy

NCT06152939 | Unknown

• 1 other identifier: LV thrombus in anterior STEMI
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

• to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary intervention (PPCI) , or thrombolytic therapy .

Conditions

Left Ventricular Thrombus

Outcome Measures

Primary Outcomes (1)

• the relation of different hematological indices to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary intervention (PPCI) or thrombolytic therapy .

  • To assess the relation of different hematological indices including platelet indices: Mean platelet volume (MPV), Mean platelet component (MPC) , Plateletcrit (PCT), platelet distribution width (PDW), Mean platelet mass (MPM), and blood cell ratios: Neutrophil to lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR),White blood cell to Mean platelet volume (WMR) to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary intervention (PPCI) or thrombolytic therapy .

  baseline

Secondary Outcomes (1)

• o Assessment of protein C, S, and activated protein C resistance (APCR) and its relation to LVT development.

  baseline

Study Arms (2)

1

patients with acute anterior ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention .

Other: Primary percutaneous coronary intervention or thrombolytic therapy

2

patients with acute anterior ST segment elevation myocardial infarction have thrombolytic therapy .

Other: Primary percutaneous coronary intervention or thrombolytic therapy

Interventions

Primary percutaneous coronary intervention or thrombolytic therapy OTHER

Primary percutaneous coronary intervention or thrombolytic therapy

1; 2

Eligibility Criteria

• Age: 15 Years - 95 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients present with acute anterior STEMI and undergoing primary percutaneous coronary intervention or thrombolytic therapy in Assiut university heart hospital (AUHH). Patients will be categorized into 2 groups: those with LVT and those without LVT development.

You may qualify if:

• All patients presented to Assiut university cardiac catheterization laboratory with acute anterior STEMI and managed with PPCI or thrombolytic therapy.

You may not qualify if:

• Patients not eligible to PPCI
• Patients presented with inferior or lateral STEMI or any type of STEMI other than anterior STEMI.

Sponsors & Collaborators

• Assiut University: lead

Related Links

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MeSH Terms

Interventions

Thrombolytic Therapy

Intervention Hierarchy (Ancestors)

Drug Therapy; Therapeutics

Central Study Contacts

Al zahraa Sayed

CONTACT

01015692124; sayedzahraa570@gmail.com

Yehia Kishk

CONTACT

01223971269; ytkishk2002@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Relation of laboratory indices to left ventricular thrombus formation in patients with acute anterior ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention or thrombolytic therapy

Study Record Dates

• First Submitted: September 19, 2023
• First Posted: December 1, 2023
• Study Start: January 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 1, 2024
• Last Updated: December 1, 2023

Record last verified: 2023-11