Acute Effects of Handgrip on Blood Pressure in Hypertensive Adults

NCT04856553 | Completed

• 1 other identifier: ACUTE HANDGRIP 2021
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

The effect of handgrip training on blood pressure reduction has been demonstrated in several studies. However, acutely, there is still divergence regarding the effects of isometric handgrip exercise on blood pressure responses, especially when it is performed at different times of the day. It is suggested that the magnitude of blood pressure reduction after a single exercise session is able to predict long-term blood pressure behavior. Thus, understanding the effects of isometric handgrip exercise, performed at different times of the day, on blood pressure in adult hypertensive individuals acutely may help to understand the effects of this type of exercise chronically.

Conditions

Hypertension

Keywords

Exercise; Blood pressure; Strength training; Vascular function

Outcome Measures

Primary Outcomes (1)

• Change in Ambulatory Blood Pressure

  The ambulatory blood pressure will be collected for a 24-hour period using an automatic device (Dyna-MAPA, Cardios, Brazil). The device, duly calibrated, will be connected to a cuff, in the arm of preference, for the evaluation measurements. The device will be programmed to take measurements throughout the day at 15-minute intervals and during the night every 30 minutes (between 11:00 p.m. and 7:00 a.m.). All subjects will be given forms to record possible eventualities during the use of the device.

  24 hours after the session

Secondary Outcomes (2)

• Change of clinical blood pressure from pre to post session

  Before, immediately after, 15 minutes and 30 minutes after the session.

• Change in vascular function from pre to post session

  Before, immediately after and 30 minutes after the session.

Study Arms (3)

Handgrip exercise (morning)

EXPERIMENTAL

The handgrip exercise session will be executed with four series (two in each arm) of two minutes of isometric contraction at 30% of maximum voluntary contraction, with a one-minute interval between series in the morning.

Other: Acute effects of handgrip exercise

Control

NO INTERVENTION

In the control session, the participants will remain at rest for the same period of time as in the handgrip exercise protocol.

Handgrip exercise (afternoon)

EXPERIMENTAL

The handgrip exercise session will be executed with four series (two in each arm) of two minutes of isometric contraction at 30% of maximum voluntary contraction, with a one-minute interval between series in the afternoon.

Other: Acute effects of handgrip exercise

Interventions

Acute effects of handgrip exercise OTHER

The participants will be randomized into three sessions, handgrip exercise in the morning, handgrip exercise in the afternoon, and control performed in the morning to analyze the acute effects of handgrip exercise on blood pressure and vascular function at different times of the day. After the morning sessions, ambulatory blood pressure will also be measured for 24 hours.

Handgrip exercise (afternoon); Handgrip exercise (morning)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of hypertension controlled by up to three antihypertensive medications;
• SBP levels ≤ 180 mmHg and/or DBP ≤110 mmHg;
• no serious heart disease;
• no upper limb musculoskeletal injury that prevents the handgrip.

You may not qualify if:

• diagnosis of other cardiovascular diseases or diabetes during the study;
• change the class and/or dose of antihypertensive medication during the study;
• worsening of the disease (BP \> 180 or use of four or more medications).

Sponsors & Collaborators

• Universidade Federal de Santa Catarina: lead

Study Sites (1)

Universidade Federal de Santa Catarina

Florianópolis, Santa Catarina, 88040-900, Brazil

Location

MeSH Terms

Conditions

Hypertension; Motor Activity

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Behavior

Study Officials

• Aline M. Gerage, Dr.

  Universidade Federal de Santa Catarina

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 14, 2021
• First Posted: April 23, 2021
• Study Start: June 1, 2021
• Primary Completion: August 30, 2021
• Study Completion: August 30, 2021
• Last Updated: September 30, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)