NCT04853862

Brief Summary

Evaluation of health-related quality of life of head and neck cancer patients undergoing immunotherapy

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started May 2021

Typical duration for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 17, 2021

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 21, 2021

Completed
10 days until next milestone

Study Start

First participant enrolled

May 1, 2021

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2023

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2023

Completed
Last Updated

April 21, 2021

Status Verified

April 1, 2021

Enrollment Period

1.9 years

First QC Date

April 17, 2021

Last Update Submit

April 17, 2021

Conditions

Keywords

head and neckimmunotherapyquality of life

Outcome Measures

Primary Outcomes (2)

  • Quality of life

    Evaluation of quality of life based on validated questionnaire

    2 years

  • Overall survival

    Overall survival

    2 years

Interventions

Questionnaire for health-related quality of life evaluation

Also known as: EORTC H&N-43

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Head and neck cancer patients undergoing systemic treatment with immunotherapy

You may qualify if:

  • Patients with a diagnosis of recurrent or metastatic squamous cell carcinoma of the head and neck region, whose planned treatment is immunotherapy, will be included. We will consider, separately, patients that had been treated with platinum before (platinum-refractory) and patients that were not submitted to this treatment (platinum naïve).
  • Primary site: patients with primary pharyngeal tumors (oro or hypopharynx), oral cavity and larynx will be included.

You may not qualify if:

  • Patients with cognitive impairment that prevents the proper application of questionnaires
  • Brain metastasis
  • Autoimmune disease
  • Systemic immunosuppressive treatment
  • Hepatitis B, C or HIV infection
  • Prior immunotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Head and Neck Neoplasms

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasms

Intervention Hierarchy (Ancestors)

Data CollectionEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Central Study Contacts

Marcos Santos, MD PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD PhD

Study Record Dates

First Submitted

April 17, 2021

First Posted

April 21, 2021

Study Start

May 1, 2021

Primary Completion

March 30, 2023

Study Completion

June 30, 2023

Last Updated

April 21, 2021

Record last verified: 2021-04

Data Sharing

IPD Sharing
Will share

Data base will be shared, if requested

Shared Documents
STUDY PROTOCOL, CSR
Time Frame
Data will be available from December 2023 to December 2028
Access Criteria
Request by email