Tajik Migrant Health Education Study

NCT04853394 | Completed Results DMC

• 2 other identifiers: 2020-0795R01DA050464
• Study Type: interventional
• Target: 420
• Locations: 1 country
• Sites: 1

Brief Summary

This study will test the efficacy of a peer-education prevention intervention to reduce risky drug, alcohol, and sexual behaviors among male Tajik labor migrants who inject drugs (MWID) while working in Moscow. The peer educator intervention will be compared to a health education control intervention. Each intervention consists of 5 weekly 2-hour small group sessions. Follow-up assessments will be conducted at 3, 6, 9, and 12 months after the intervention. It is hypothesized that, compared to MWID who receive the health education control intervention, those who receive the peer educator intervention will have a greater reduction in the frequency of risk behaviors. Similar effects are expected for network members of intervention participants.

Conditions

HIV Infections; Hepatitis C; Risky Health Behavior; Risk Reduction Behavior

Keywords

injection drug use; migrant workers; risk behavior

Outcome Measures

Primary Outcomes (3)

• Syringe Sharing

  injected with a previously used syringe

  3 months

• Sex Without Condom

  vaginal or anal sex without a condom in the past 3 months

  3 months

• Alcohol Use

  Number of days drinking alcohol in past month

  30 days

Secondary Outcomes (2)

• HIV Infection

  12 months

• Hepatitis C Infection

  12 months

Other Outcomes (1)

• Injection Equipment Sharing

  3 months

Study Arms (2)

MASLIHAT peer education

EXPERIMENTAL

A peer educator prevention intervention program consisting of five weekly 2-hour small group sessions.

Behavioral: MASLIHAT

TANSIHAT health education

SHAM COMPARATOR

A health education program consisting of five weekly 2-hour sessions small group sessions.

Behavioral: TANSIHAT

Interventions

MASLIHAT BEHAVIORAL

peer educator intervention

MASLIHAT peer education

TANSIHAT BEHAVIORAL

health education intervention

TANSIHAT health education

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adult Tajik man
• injected drugs in past 30 days
• living and working as migrant laborer in Moscow

You may not qualify if:

• does not intend to stay in Moscow for the next 12 months

Sponsors & Collaborators

• University of Illinois at Chicago: lead
• National Institute on Drug Abuse (NIDA): collaborator
• Prisma Research Center: collaborator

Study Sites (1)

PRISMA Research Center

Moscow, Russia

Location

Related Publications (5)

• Mackesy-Amiti ME, Levy JA, Bahromov M, Jonbekov J, Luc CM. HIV and Hepatitis C Risk among Tajik Migrant Workers Who Inject Drugs in Moscow. Int J Environ Res Public Health. 2023 May 24;20(11):5937. doi: 10.3390/ijerph20115937.

  PMID: 37297541 BACKGROUND

• Luc CM, Levy J, Bahromov M, Jonbekov J, Mackesy-Amiti ME. HIV knowledge, self-perception of HIV risk, and sexual risk behaviors among male Tajik labor migrants who inject drugs in Moscow. BMC Public Health. 2024 Jan 11;24(1):156. doi: 10.1186/s12889-023-17543-1.

  PMID: 38212755 BACKGROUND

• Mackesy-Amiti ME, Bahromov M, Levy JA, Jonbekov J, Luc CM. Changes in risk behaviour following a network peer education intervention for HIV prevention among male Tajik migrants who inject drugs in Moscow: a cluster-randomized controlled trial. J Int AIDS Soc. 2024 Jul;27 Suppl 3(Suppl 3):e26310. doi: 10.1002/jia2.26310.

  PMID: 39030891 RESULT

• Mackesy-Amiti ME, Levy JA, Luc CM, Jonbekov J. Peer education intervention reduced sexually transmitted infections among male Tajik labor migrants who inject drugs: results of a cluster-randomized controlled trial. BMC Public Health. 2025 Jun 10;25(1):2154. doi: 10.1186/s12889-025-23387-8.

  PMID: 40495129 DERIVED

• Mackesy-Amiti ME, Levy JA, Luc CM, Jonbekov J. Peer Education Intervention Reduced Sexually Transmitted Infections Among Male Tajik Labor Migrants Who Inject Drugs: Results of a Cluster-randomized Controlled Trial. medRxiv [Preprint]. 2025 May 1:2024.08.15.24312070. doi: 10.1101/2024.08.15.24312070.

  PMID: 39185538 DERIVED

Related Links

• Open Science Framework Project page
• Data files

MeSH Terms

Conditions

HIV Infections; Hepatitis C; Health Risk Behaviors; Risk Reduction Behavior; Risk-Taking

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Hepatitis, Viral, Human; Flaviviridae Infections; Hepatitis; Liver Diseases; Digestive System Diseases; Health Behavior; Behavior

Results Point of Contact

• Title: Mary E. Mackesy-Amiti
• Organization: University of Illinois Chicago

mmamiti@uic.edu

312-355-4892

Study Officials

• Mary E Mackesy-Amiti, Ph.D.

  University of Illinois at Chicago

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Associate Professor

Model Details: cluster-randomized parallel groups

Study Record Dates

• First Submitted: April 16, 2021
• First Posted: April 21, 2021
• Study Start: October 19, 2021
• Primary Completion: May 4, 2023
• Study Completion: May 28, 2023
• Last Updated: December 6, 2024
• Results First Posted: December 6, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
• Time Frame: The data will be made available upon study completion.
• Access Criteria: Access will be provided upon request with a description of the intended use.

Locations

RU (1)