Effect of Honey and Dexamethason on Extraction Healing
A Novel Therapeutic Approach for Controlling Complications Associated With Impacted Mandibular Third Molar Removal
1 other identifier
interventional
80
1 country
1
Brief Summary
Natural honey and dexamethason will be given before impaction removal then postoperative complications will be evaluated
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for early_phase_1
Started Jan 2021
Shorter than P25 for early_phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 5, 2021
CompletedFirst Submitted
Initial submission to the registry
April 14, 2021
CompletedFirst Posted
Study publicly available on registry
April 19, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 20, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 27, 2021
CompletedJuly 22, 2021
July 1, 2021
6 months
April 14, 2021
July 20, 2021
Conditions
Outcome Measures
Primary Outcomes (9)
Interincisal distance
Distance between upper and lower teeth will be measured in mm by ruler
Preoperative
Interincisal distance
Distance between upper and lower teeth will be measured in mm by ruler
I day postoperative
Interincisal distance
Distance between upper and lower teeth will be measured in mm by ruler
3rd day postoperative
Interincisal distance
Distance between upper and lower teeth will be measured in mm by ruler
7th day postoperative
Edema
Measured from angle of mandible to angle of mouth
Preoperative
Edema
Measured from angle of mandible to angle of mouth
1day postoperative
Edema
Measured from angle of mandible to angle of mouth in mm by ruler
2nd day postoperative
Edema
Measured from angle of mandible to angle hof mouth in mm by ruler
3rd day postoperative
Edema
Measured from angle of mandible to angle of mouth in mm by ruler
7th day postoperative
Study Arms (4)
Control
PLACEBO COMPARATORNo drug given before surgery
Dexamethason
ACTIVE COMPARATORDexamethason will be given IV before surgery
Natural honey
ACTIVE COMPARATORHoney will be placed locally after impaction removal
Dexamethason and natural honey
ACTIVE COMPARATORDexamethason will be given IV before surgery and Honey will be placed locally after impaction removal
Interventions
Dexamethason will be given IV before surgery and then Honey will be applied locally after surgery
Eligibility Criteria
You may qualify if:
- impacted 3rd molar
- healthy patient No smoking
You may not qualify if:
- history of smoking Medical disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vision colleges
Jeddah, Saudi Arabia
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
April 14, 2021
First Posted
April 19, 2021
Study Start
January 5, 2021
Primary Completion
June 20, 2021
Study Completion
June 27, 2021
Last Updated
July 22, 2021
Record last verified: 2021-07