Acute Salt Sensitivity of Blood Pressure
AcuteSS
HIV Integrated Personalized Care Approach to the Prevention, Diagnosis, and Control of Salt-sensitive Hypertension: The HIPO CAP DICTSH STUDY
1 other identifier
interventional
132
1 country
1
Brief Summary
Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Dec 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2021
CompletedFirst Submitted
Initial submission to the registry
April 9, 2021
CompletedFirst Posted
Study publicly available on registry
April 14, 2021
CompletedApril 15, 2021
April 1, 2021
3 months
April 9, 2021
April 13, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Acute salt sensitivity
Mean arterial pressure change of 10 mmHg
160 minutes
Secondary Outcomes (2)
Diastolic blood pressure change
160 minutes
Systolic blood pressure change
160 minutes
Study Arms (1)
Pre and post intervention group
OTHERSame individuals are examined before and after taking 2 tablets of salt
Interventions
Eligibility Criteria
You may qualify if:
- Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study)
You may not qualify if:
- diabetes patients, ill participants
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mulungushi Universitylead
- University of Zambiacollaborator
Study Sites (1)
Livingstone Central Hospital
Livingstone, Southern Province, 10101, Zambia
Related Publications (1)
Masenga SK, Hamooya BM, Patel KP, Kirabo A. Erythrocyte glycocalyx sensitivity to sodium is associated with salt sensitivity of blood pressure in women but not men. Front Nutr. 2024 Mar 8;11:1334853. doi: 10.3389/fnut.2024.1334853. eCollection 2024.
PMID: 38524849DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sepiso K Masenga, PhD
Mulungushi University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
April 9, 2021
First Posted
April 14, 2021
Study Start
December 1, 2020
Primary Completion
February 28, 2021
Study Completion
February 28, 2021
Last Updated
April 15, 2021
Record last verified: 2021-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- After publishing results
- Access Criteria
- email and published article (open access)
Individual participant data will be made available after publication upon request.