Influence of Tart Cherry Juice Intervention on Vascular Function

NCT04840160 | Completed

• 1 other identifier: lucymurray2016
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action

Conditions

Dietary Exposure; Metabolic Disturbance

Keywords

cherry; anthocyanin; vascular function; metabolomics

Outcome Measures

Primary Outcomes (3)

• Systolic and diastolic blood pressure

  Measurement of systolic and diastolic blood pressure before and after the intervention

  Change in blood pressure following 4 weeks intervention

• Arterial pulse wave velocity

  Measurement of pulse wave velocity before and after the intervention

  Change in pulse wave velocity following 4 weeks intervention

• Digital volume pulse

  Measurement of digital volume pulse before and after the intervention

  Change in digital volume pulse following 4 weeks intervention

Secondary Outcomes (1)

• Metabolomics

  Changes to urinary metabolite profiles following 4 weeks intervention

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Participants supplied with 30 ml of a low fruit (\<1%) cordial mixed with maltodextrin and protein diluted in 100 ml water twice daily, once in the morning and evening.

Dietary Supplement: Placebo

Cherry juice

EXPERIMENTAL

Participants supplied with 30 ml of a tart cherry juice concentrate (CherryActive, United Kingdom; (containing 36.8 mg of anthocyanins) diluted in 100 ml of water twice daily, once in the morning and evening.

Dietary Supplement: Cherry juice

Interventions

Cherry juice DIETARY_SUPPLEMENT

A tart cherry juice intervention

Cherry juice

Placebo DIETARY_SUPPLEMENT

A tart cherry juice placebo

Placebo

Eligibility Criteria

• Age: 19 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• aged 19-40
• no diagnosed issues with the ability to consume fruit juice
• no known food intolerances to fruits

You may not qualify if:

• participants that are cigarette smokers
• participants diagnosed with hypertension
• participants diagnosed with any form of cardiometabolic diseases
• participants that require any prescribed prescriptions excluding the contraceptive pill
• participants that are regular consumers of cherries (\>100 g/d)
• participants that consume any antioxidant supplements

Sponsors & Collaborators

• Northumbria University: lead

Study Sites (1)

Northumberland Building

Newcastle upon Tyne, NE1 7ST, United Kingdom

Location

Study Officials

• Glyn Howatson

  Northumbria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Participants supplied with treatment or placebo in a plastic container
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomised controlled trial

Study Record Dates

• First Submitted: April 6, 2021
• First Posted: April 9, 2021
• Study Start: April 1, 2016
• Primary Completion: August 1, 2017
• Study Completion: August 1, 2019
• Last Updated: April 9, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)