Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

NCT04830995 | Completed

• 1 other identifier: Cairo Un100
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Conditions

High Intensity Interval Training; Diet, Healthy

Keywords

Training; Insulin Resistance; Pregnancy

Outcome Measures

Primary Outcomes (1)

• Fasting blood glucose level

  Fasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.

  three months

Secondary Outcomes (1)

• Fasting Insulin Level

  three months

Study Arms (2)

diet program

EXPERIMENTAL

moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly

Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

high intensity interval training

EXPERIMENTAL

high intensity interval training for four weeks, 3 sessions weekly

Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

Interventions

moderate restricted diet (1800-2000 kcal/day) for four weeks DIETARY_SUPPLEMENT

high intensity interval training 3 sessions for four weeks

Also known as: high intensity interval training

diet program; high intensity interval training

Eligibility Criteria

• Age: 25 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• forty multigravida females.
• their age ranged between 25 to 35 years old.
• Body mass index (BMI) \<30kg/ m².

You may not qualify if:

• females with pelvic pathology as endometriosis.
• females have irregular menstrual cycles.

Sponsors & Collaborators

• Cairo University: lead
• Heba mohamed Embaby: collaborator
• Salwa Elgendy: collaborator

Study Sites (1)

Ghada Elrefaye

Giza, 12613, Egypt

Location

MeSH Terms

Conditions

Insulin Resistance

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Randomization was done by sealed envelope
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor Department of Physical Therapy for Women's Health, Faculty of Physical therapy, Cairo University, Egypt

Model Details: group (A) received HIIT and low diet for four weeks, 3 sessions weekly. While the control group received diet only.

Study Record Dates

• First Submitted: April 1, 2021
• First Posted: April 5, 2021
• Study Start: March 24, 2020
• Primary Completion: October 30, 2020
• Study Completion: November 1, 2020
• Last Updated: January 19, 2023

Record last verified: 2023-01

Locations

EG (1)