NCT04823663

Brief Summary

SOCRATES is part of Boston Scientific's (BSC) Post-market surveillance system. The implementation of such systems is mandatory per local regulations such as the Regulation '(EU) 2017/745 of the European Parliament and of the Council of 5 April 2017 on medical devices' or short Medical Device Regulation (MDR). The SOCRATES design is therefore based on the BSC's commitment as well as external regulatory requirements to proactively and systematically gather, record and analyze relevant data on the quality, performance and safety of devices throughout their entire lifetime.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12,500

participants targeted

Target at P75+ for all trials

Timeline
57mo left

Started Mar 2021

Longer than P75 for all trials

Geographic Reach
10 countries

26 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress52%
Mar 2021Dec 2030

First Submitted

Initial submission to the registry

March 18, 2021

Completed
13 days until next milestone

Study Start

First participant enrolled

March 31, 2021

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 1, 2021

Completed
9.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

9.8 years

First QC Date

March 18, 2021

Last Update Submit

April 27, 2026

Conditions

Outcome Measures

Primary Outcomes (3)

  • System-related complication free rate

    Freedom from complications related to system

    From Cardiac Rhythm Management (CRM) device implant on day 0 through follow-up up to 10 years; from electrophysiological (EP) procedure on day 0 through follow-up from 30 days up to 1 year

  • Rate of product related performance deficiencies per product or product group

    Performance of product/product group at implant/procedure

    CRM implant on day 0; EP procedure on day 0

  • Rate of product related performance deficiencies per product or product group

    Performance of product/product group through the implanted duration

    CRM implant on day 0 through the implanted duration up to 10 years

Study Arms (1)

BSC Product Use

Subject fulfilling one of the following conditions: a. prospectively scheduled for a procedure involving i. use of a BSC EP Ablation product or BSC Capital Equipment product or ii. a BSC CRM product implant or b. retrospectively enrolled no more than 10 days after the index procedure and and all data necessary for appropriate reporting of all past visits is available and complete including i. the procedure where being diagnosed or treated with at least 3 separate BSC EP Ablation products/components or BSC Capital Equipment products/components or ii.the BSC CRM product implant.

Device: ImplantProcedure: Electrophysiologic procedure

Interventions

ImplantDEVICE

In the scope of the CRM procedure and subsequent follow-up, the registry will provide information on the use of the Boston Scientific CRM products/components and combination of those products/components with competitor product(s) per hospital's standard of care.

BSC Product Use

In the scope of the EP procedure and subsequent follow-up, the registry will provide information on the use of the Boston Scientific Electrophysiology products/components and capital equipment products and combination of those products/components with competitor product(s) per hospital's standard of care.

BSC Product Use

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The subjects will be recruited from the general patient population of the participating centers who are * receiving diagnosis or treatment using a BSC product in scope of SOCRATES and * fulfilling all inclusion criteria and none of the exclusion criteria.

You may qualify if:

  • Subject is willing and capable of providing informed consent and/or to give approval to collect/store/process personal health information by the sponsor or such consent/approval is provided by a legally designated representative, if required by local law or regulation.
  • Subject is (one criterion must be fulfilled) a. prospectively scheduled for a procedure involving i. use of a BSC EP Ablation product or BSC Capital Equipment product or ii. a BSC CRM product implant or b. retrospectively enrolled no more than 10 days after the index procedure and all data necessary for appropriate reporting of all past visits is available and complete including i. the procedure where being diagnosed or treated with at least 3 separate BSC EP Ablation products/components or BSC Capital Equipment products/components or ii. the BSC CRM product implant.

You may not qualify if:

  • Subject is foreseen not to be followed at the enrolling center for at least 1 year after an implant procedure (CRM) or at least 1 month (EP).
  • Subject is receiving diagnosis or therapy by means of any product, that is not approved for commercial use at the time of implant/procedure.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (26)

Universitair Ziekenhuis Brussel

Jette, 1090, Belgium

RECRUITING

CHU UCL Namur - Site Godinne

Yvoir, 5530, Belgium

RECRUITING

Institut Universitaire de Cardiologie et de Pneumologie de Quebec

Québec, Quebec, G1V 4G5, Canada

RECRUITING

CHRU de Brest, Hôpital de la Cavale Blanche

Brest, 29200, France

RECRUITING

CHRU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

RECRUITING

Hopital Saint Philibert

Lomme, 59462, France

RECRUITING

CHG de Pau

Pau, France

RECRUITING

CHU de Saint-Etienne

Saint-Etienne, 42055, France

RECRUITING

Unfallkrankenhaus Berlin Marzahn

Berlin, 12687, Germany

RECRUITING

Augusta Kranken Anstalt GmbH

Bochum, 44791, Germany

COMPLETED

General Hospital of Athens "G. Gennimatas"

Athens, 11527, Greece

COMPLETED

Onassis Cardiac Surgery Center

Athens, 17674, Greece

RECRUITING

Mater Private Hospital

Dublin, D07 WKW8, Ireland

RECRUITING

Sheba Medical Center

Ramat Gan, 52621, Israel

RECRUITING

Tel Aviv Sourask Medical Center

Tel Aviv, 62431, Israel

RECRUITING

Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

RECRUITING

Policlinico di Modena

Modena, 41124, Italy

RECRUITING

Policlinico Universitario Agostino Gemelli

Roma, 00168, Italy

RECRUITING

Policlinico Casilino

Roma, 00169, Italy

RECRUITING

Ospedale S.G. Calibita Fatebenefratelli - Isola Tiberina

Roma, 00186, Italy

RECRUITING

Hospital Clinico San Carlos

Madrid, 28040, Spain

RECRUITING

Hospital Universitario de Canarias

San Cristóbal de La Laguna, 38320, Spain

RECRUITING

Hospital Nuestra Señora de La Candelaria

Santa Cruz de Tenerife, 38010, Spain

RECRUITING

Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain

RECRUITING

St. Bartholomew's Hospital

London, EC1A 7BE, United Kingdom

RECRUITING

Manchester Heart Center

Manchester, M13 9WL, United Kingdom

RECRUITING

MeSH Terms

Conditions

Heart Diseases

Interventions

Mutagenesis, Insertional

Condition Hierarchy (Ancestors)

Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Protein EngineeringGenetic EngineeringGenetic TechniquesInvestigative TechniquesMutationGenetic VariationGenetic PhenomenaMutagenesis

Study Officials

  • Eszter Pais, MD

    Boston Scientific Corporation

    STUDY DIRECTOR

Central Study Contacts

Maria Paz Lopez-Chicharro

CONTACT

Jens B Goetzke, Dipl.Ing.

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
10 Years
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 18, 2021

First Posted

April 1, 2021

Study Start

March 31, 2021

Primary Completion (Estimated)

December 31, 2030

Study Completion (Estimated)

December 31, 2030

Last Updated

April 29, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations