The Longterm Risk of Advanced Colorectal Neoplasia After Colonoscopy - A Population-based Cohort Study in Hong Kong

NCT04815525 | Recruiting DMC

• 1 other identifier: 2020.597
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to analyze the 15-year cumulative incidence of advanced colorectal neoplasia and CRC-related mortality after the index colonoscopy.

Conditions

Colorectal Neoplasia; Colorectal Cancer

Keywords

colonoscopy

Outcome Measures

Primary Outcomes (1)

• Culumative incidence of advanced colorectal neoplasia

  high-risk adenomas or CRC after 15 years of index conoloscopy

  15 years

Secondary Outcomes (1)

• CRC-related mortality rate

  15 years

Study Arms (4)

Normal finding

Colonoscopy finding normal

Hyperplastic polyps

Colonoscopy finding of hyperplastic polyps

Low-risk adenomas

Colonoscopy finding of low-risk adenomas

High-risk adenomas

Colonoscopy finding of high-risk adenomas

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will identify patients from CDARS with colonoscopy performed from 1 January 2000 to 31 October 2020. Other relevant diagnoses, procedures, concomitant drugs, laboratory parameters and pathology results will be retrieved and studied.

You may qualify if:

• \. All patients with colonoscopy performed in HA hospitals during the study period would be eligible for screening.

You may not qualify if:

• \. Patients with documented personal history of colorectal cancers before the study period would be excluded.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Prince of Wales Hospital

Shatin, New Territories, Hong Kong

RECRUITING

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Central Study Contacts

Felix Sia

CONTACT

+85226370428; felix.sia@cuhk.edu.hk

Thomas Lam

CONTACT

+85226370428; thomas.lam@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Specialist

Study Record Dates

• First Submitted: March 23, 2021
• First Posted: March 25, 2021
• Study Start: January 1, 2023
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: February 9, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)